Reagents

Wash Buffer (10X) for ELISA

Reference: AG-10B-0001EK

€0.00 (tax incl.)

ELISA Kit Component: Wash Buffer (30ml) - Suitable amount for all AG-45A-XXXXEK and AG-45B-XXXXEK single box ELISA Kits.

ELISA Buffer (10X)

Reference: AG-10B-0002EK

€0.00 (tax incl.)

ELISA Kit Component: ELISA Buffer (30ml) - Suitable amount for all AG-45A-XXXXEK and AG-45B-XXXXEK single box ELISA Kits.

TMB Substrate Solution for ELISA

Reference: AG-10B-0003EK

€0.00 (tax incl.)

ELISA Kit Component: TMB Substrate Solution (12ml) - Suitable amount for all AG-45A-XXXXEK and AG-45B-XXXXEK single box ELISA Kits.

Stop Solution for ELISA

Reference: AG-10B-0004EK

€0.00 (tax incl.)

ELISA Kit Component: Stop Solution (12ml) - Suitable amount for all AG-45A-XXXXEK and AG-45B-XXXXEK single box ELISA Kits.

Loading Buffer (5X)

Reference: AG-10T-0020

€0.00 (tax incl.)

Loading buffer for separation and visualization proteins with SDS-PAGE and Western Blot analysis.

Pre-coupled Mg-ATP is an ideal energy source for semi-purified conjugation/degradation reactions. Supplied as a pH adjusted solution and will not alter reaction pH. Eliminates the reaction needed to produce usable ATP...

IPTG (animal-free, dioxane-free)

Reference: AG-CC1-0002

€0.00 (tax incl.)

Molecular biology reagent. beta-Galactosidase activity inducer in several bacteria, by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called...

X-Gal

Reference: AG-CC1-0003

€0.00 (tax incl.)

Molecular biology reagent. Chromogenic substrate for beta-galactosidase. Used in gene cloning together with IPTG (Prod. No. AG-CC1-0002) to indicate whether a cell expresses the beta-galactosidase enzyme, which is...

n-Dodecyl-beta-D-maltoside (ultrapure)

Reference: AG-CC1-0004

€0.00 (tax incl.)

Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes.

n-Octyl-beta-D-thioglucopyranoside (ultrapure)

Reference: AG-CC1-0005

€0.00 (tax incl.)

Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. The thioether linkage makes it resistant to degradation by beta-glucosidase enzymes. For the stabilization and...

n-Dodecyl-alpha-D-maltoside (ultrapure)

Reference: AG-CC1-0006

€0.00 (tax incl.)

Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes.

MEGA-8 (ultrapure)

Reference: AG-CC1-0007

€0.00 (tax incl.)

Non-ionic water-soluble detergent with nondenaturing properties. Transparent in the UV region. Relatively high critical micelle concentration (CMC) value (79mM/l). Ideal for studying the conformation and function of...

n-Octyl-beta-D-glucopyranoside (ultrapure)

Reference: AG-CC1-0008

€0.00 (tax incl.)

Non-ionic detergent for the functional solubilization, isolation, purification and crystallograpy of membrane proteins. Mild, non-denaturing detergent that is used for the solubilization and reconstitution of...

Prostaglandin E2

Reference: AG-CL1-0001

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One of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme and acts on four kinds of receptor subtypes (EP1, EP2, EP3 and EP4) with high binding...

Ageladine A . trifluoracetate

Reference: AG-CMA-1001

€0.00 (tax incl.)

Non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, vesicles, cells, tissue and even small whole animals over several days without side effects...

LysoGlow84™

Reference: AG-CMA-1005

€0.00 (tax incl.)

Cell/membrane permeable, non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, lysosomes, autophagolysosomes, vesicles, cells, tissue and even small,...

Skyrin

Reference: AG-CN2-0001

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Non-peptidic anti-diabetic agent [1]. Receptor-selective glucagon antagonist [1]. Free radical species (·OH, R·) and singlet oxygen (1O2) scavenger [2]. Mycotoxin [3, 4]. Cytotoxic [3, 4]. Antioxidant [2]. Inhibitor...

Thapsigargin (high purity)

Reference: AG-CN2-0003

€0.00 (tax incl.)

Intracellular Ca2+ signaling probe [1]. Specific and sensitive inhibitor of SERCA [2]. Non-TPA/PMA tumor promoter [3]. Histamine release inducer [4]. Apoptosis inducer [5, 6, 7, 8]. Mitochondrial dysfunction...

Zerumbone

Reference: AG-CN2-0004

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Chemopreventive probe. Apoptosis inducer. Potent anti-tumor compound. Sonic hedgehog signaling pathway inhibitor. Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-kappaB...

Anomalin A

Reference: AG-CN2-0006

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Antiproliferative agent against selected cancer cell lines. Inhibits protein kinases ALK, ARK5, Aurora-B, AXL, FAK, IGF1-R, MET, PIM1, PLK1, PRK1, SRC, and VEGF-R2 with IC50 values between 0.3 and 75.7µM, most...

Ferutinin (high purity)

Reference: AG-CN2-0007

€0.00 (tax incl.)

Potent, naturally occuring non-steroid estrogenic compound. Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) [1, 3, 4]....

Hyperforin . DCHA

Reference: AG-CN2-0008

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Key constituent of St. John's wort. Shows properties of potential pharmacological interest, including antibacterial [1], anti-malarial [13], anti-inflammatory [7, 14], anti-cancer and anti-angiogenic effects [5, 10]....

Pellitorine

Reference: AG-CN2-0009

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Tingling-inducing agent. Excellent stable model compound for sensory studies [3]. Exerts same profile as the unstable compound hydroxy-alpha-sanshool. Shows larvicidal, antimycobacterial and antituberculosis activity...

Phorbol 12-myristate 13-acetate

Reference: AG-CN2-0010

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PMA/TPA is the most commonly-used phorbol ester [1,2]. Binds to and activates protein kinase C (PKC) at nM concentrations [1,2,9]. Induces cell growth arrest through a variety of pathways including the...

Ferulenol

Reference: AG-CN2-0011

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Prenylated 4-hydroxycoumarin. Anti-tumor compound [2]. Cytotoxic [2]. Stimulator of tubulin polymerization in vitro [2]. Inhibitor of colchicine binding to tubulin [2]. Antitubercular antibiotic with potent...

Ingenol-3-angelate

Reference: AG-CN2-0012

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Specific protein kinase C (PKC) activator [1]. Selective activator of PKC isoforms, like PKCtheta in T cells [1, 5, 8]. Antiproliferative and proapoptotic (necrotic) [2, 3, 5]. Immunostimulant [6]. Chemotherapeutic...

alpha-Galactosylceramide

Reference: AG-CN2-0013

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Immunostimulant [1, 2, 3]. Potent stimulator of natural killer T (NKT) cells [4, 5]. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells [5]. Protects against LPS-induced...

(25S)-Delta7-Dafachronic acid

Reference: AG-CN2-0014

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Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes [1, 2, 3]. Sterol-derived hormone. Blocks...

(-)-Ageloxime D

Reference: AG-CN2-0016

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Quaternary ammonium compound. Antifouling compound. Inhibits biofilm formation but not bacterial growth of Staphylococcus epidermidis. Anticancer compound. Cytotoxic against L5178Y mouse lymphoma cells.

Phomoxanthone A

Reference: AG-CN2-0017

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Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK...

(+)-Brefeldin A

Reference: AG-CN2-0018

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Protein transport from ER to Golgi inhibitor [2, 3]. ADP-ribosylation factor (Arf) inhibitor [6]. Cytotoxic [1]. Antibiotic [8]. Antiviral [8]. Apoptosis inducer [5]. Antitumor compound [9]. Intracellular collagen...

K-252a

Reference: AG-CN2-0019

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Antibiotic [1]. PKC, PKA and PKG inhibitor [1, 2, 4]. Shows neurotropic activity by inducing neurite outgrowth [3, 8, 11,16]. Highly potent cell permeable CaM kinase [6] and phosphorylase inhibitor [5]. Tyrosine...

Nigericin . sodium salt

Reference: AG-CN2-0020

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Antibiotic [1]. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+ [2, 3, 4, 7, 10]. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity [3, 6]. Disrupts membrane...

Radicicol

Reference: AG-CN2-0021

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Antibiotic [1]. Protein tyrosine kinase inhibitor [1]. Has antifungal [4], antimalarial [6], antiangiogenic (in vivo) [2], anti-inflammatory [5] and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor...

Staurosporine

Reference: AG-CN2-0022

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Antibiotic. Antifungal and anti-yeast activity [1]. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation [2]. Potent, cell permeable, reversible,...

Wortmannin

Reference: AG-CN2-0023

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Antibiotic [1]. Potent anti-neutrophil agent with cardioprotective effects [1, 13]. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor...

Piperlongumine

Reference: AG-CN2-0024

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Cytotoxic against tumor cell lines [3, 4, 5]. Induces necrosis and apoptosis in cancer cells [5, 9, 12]. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in...

Rapamycin

Reference: AG-CN2-0025

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Antibiotic. Antibacterial and antifungal properties [1, 2]. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks...

Bilobalide

Reference: AG-CN2-0026

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Neuroprotective [2, 3, 4, 5, 7]. Mitochondrial gene expression regulator [3]. ROS scavenger [4]. Competitive GABA(A) receptor antagonist [6]. Apoptosis inhibitor [4, 7, 10, 11]. CREB phosphorylation enhancer....

Latrunculin A

Reference: AG-CN2-0027

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Cell permeable marine toxin [1]. Disrupts microfilament-mediated processes [2]. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin [1, 2, 3, 6]. Depolymerizes...

Cyclopamine

Reference: AG-CN2-0028

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Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened) [1-4]. Teratogenic [1] and antitumor compound. Inhibits tumor cell growth and...

Ingenol-5,20-acetonide

Reference: AG-CN2-0029

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Intermediate and starting material for the synthesis and preparation of ingenol 3-ester derivatives. For use in chemical synthesis see references. Has improved shelf life compared to ingenol.

G418 . sulfate

Reference: AG-CN2-0030

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Antibiotic [1]. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis [1, 3, 4, 6]. Apoptosis inducer [5]. Widely employed in the selection of eukaryotic expression vectors, in combination...

Latrunculin B

Reference: AG-CN2-0031

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Cell permeable marine toxin [1]. Disrupts microfilament-mediated processes [2]. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin [1, 2, 3]. Depolymerizes...

Sauchinone

Reference: AG-CN2-0032

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Hepatoprotective antioxidant [1, 2, 9]. Anti-inflammatory. Suppresses NF-kB p65 activity [3, 5]. Neuroprotective. Apoptosis inhibitor [4]. Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation [6]....

Resveratrol

Reference: AG-CN2-0033

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Potent phenolic antioxidant found in grapes and red wine [1, 19]. Eicosanoid synthesis and platelet aggregation inhibitor [2]. Estrogen receptor agonist [3]. Chemopreventive [4, 15]. Specific inhibitor of...

16-epi-Latrunculin B

Reference: AG-CN2-0034

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Antiviral (against herpes simplex type 1 virus (HSV-1)) [1]. Cytotoxic [1, 5]. Depolymerizes actin filaments (F-actin) [2, 3, 4].

Swinholide A

Reference: AG-CN2-0035

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Cell permeable dimeric dilactone macrolide [1]. Cytotoxic compound [1, 2, 7]. Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering actin dimers and rapidly severing actin...

Resveratrol (synthetic)

Reference: AG-CN2-0036

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Potent phenolic antioxidant found in grapes and red wine [1, 19]. Eicosanoid synthesis and platelet aggregation inhibitor [2]. Estrogen receptor agonist [3]. Chemopreventive [4, 15]. Specific inhibitor of...

Jasplakinolide (high purity)

Reference: AG-CN2-0037

€0.00 (tax incl.)

Cell permeable, non-fluorescent F-actin probe [3, 8, 12]. Potent inducer of actin polymerization and stabilization [3, 8, 12]. Competes with phallotoxins for actin binding [3]. Antifungal and antiparasitic compound...

Ilimaquinone

Reference: AG-CN2-0038

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Cytoplasmic microtubule inhibitor [2, 6]. Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound [1, 11]. Induces a complete and reversible breakdown/disruption of Golgi membranes into...

Kaempferitrin

Reference: AG-CN2-0039

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Cytotoxic and anti-inflammatory compound (weak) [1, 4, 8, 10, 11]. Antioxidant [2, 5]. Lipid peroxidation inhibitor [2, 5]. Free radical scavenger [2, 5]. Inhibitor of myeloperoxidase activity [2, 5]. Hypoglycemic....

Tetrahydrobostrycin

Reference: AG-CN2-0040

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Antibiotic. Antibacterial (weak) [1]. Anticancer compound (weak) [1, 2].

Phenylmethylene hydantoin

Reference: AG-CN2-0041

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Anticancer compound [2, 3, 5, 6]. Chemopreventive [2, 3, 5, 6, 7]. Shows anti-metastatic activity in prostate cancer cells through enhancement of cell-cell adhesion [2, 3]. Anti-invasive compound [5, 6, 7]. Glycogen...

(3S,6R)-Lateritin

Reference: AG-CN2-0042

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N-methylated peptide that is structurally equivalent to a monomer of beauvericin (Prod. No. AG-CN2-0043) [3, 4]. Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 5]. Platelet aggregation inhibitor [2, 5]....

Beauvericin

Reference: AG-CN2-0043

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Antibiotic [4]. Mycotoxin. Apoptosis inducer [1, 3, 8, 9, 18]. Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [2]. Anticancer compound [3, 7, 9]. Antihaptotactic and antimetastatic [10]. Antiangiogenic compound...

Avarol

Reference: AG-CN2-0044

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Antibacterial against selected Gram-positive strains, antifungal [1, 6]. Anticancer compound [2]. Antileukemic [4, 5, 8, 9]. Antimitotic agent [3]. Antiviral compound [7, 8, 14]. Inhibits HIV activity [7, 8, 14]....

Paclitaxel

Reference: AG-CN2-0045

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Anticancer compound [1, 11, 14]. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma [11, 12]. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin [2, 3, 6, 13,...

Streptozotocin

Reference: AG-CN2-0046

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Antibiotic [1]. Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells [2, 5, 13, 14]. Mutagenic [3, 10]. Potent alkylating agent. Potent DNA...

FK-506

Reference: AG-CN2-0047

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Potent immunosuppressant (as cyclosporin A and rapamycin) [1-3]. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2) [2, 4]. Forms a...

Colchicine

Reference: AG-CN2-0048

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Anti-cancer compound [5]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 2, 5, 6]. Inhibits mitosis during cell division at...

Podophyllotoxin

Reference: AG-CN2-0049

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Potent microtubule assembly inhibitor [1-3]. Anticancer compound [1-5, 7]. Cell death inducer [1-5, 7]. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase [2, 6, 8]. Antiviral [3, 4, 9] and...

Orlistat

Reference: AG-CN2-0050

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Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor [1-3]. Anti-obesity and antihypercholesterolemic compound [2, 5, 11]. Antitumor compound by inhibition of the...

Lovastatin

Reference: AG-CN2-0051

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Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the...

Simvastatin

Reference: AG-CN2-0052

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Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid...

Ponasterone A

Reference: AG-CN2-0053

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A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to muristerone A. Functional, reliable and economical substitute for muristerone A as an inducer for the...

Sclerotiorin

Reference: AG-CN2-0054

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Antibiotic [4, 6, 7]. Antibacterial [4, 6, 7] with anticancer activity [8]. Weak antagonist of human endothelin receptor A (ETA) and B (ETB) [1]. Cholesteryl ester transfer protein (CETP) activity inhibitor [2]....

Astaxanthin

Reference: AG-CN2-0055

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Potent antioxidant carotenoid [1]. Free radical scavenger [1, 3]. Reduces oxidative stress [1, 3]. Anticancer compound [2]. Anti-inflammatory. Blocks NF-kappaB activation [3, 18]. Anti-hypertensive. Cardiovascular...

Okadaic acid (high purity)

Reference: AG-CN2-0056

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Non-phorbol type tumor promoter [1]. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C [2, 6, 7, 18]....

Fostriecin

Reference: AG-CN2-0057

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Antibiotic [1, 2, 18]. Anticancer compound [1-5, 8, 9, 11]. Antifungal [6]. Catalytic inhibitor of topoisomerase II (IC50 = 40 µM) [7, 16]. Potent protein phosphatase 2A (PP2A) (IC50 = 1.5 nM) and 4 (PP4) (IC50 = 3...

Okadaic acid . ammonium salt (high purity)

Reference: AG-CN2-0058

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Non-phorbol type tumor promoter [1]. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C [2, 6, 7, 18]....

Curcumin (high purity)

Reference: AG-CN2-0059

€0.00 (tax incl.)

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor...

(-)-Epigallocatechin gallate

Reference: AG-CN2-0063

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Potent anticancer compound. Anti-angiogenic. VEGF, VE-cadherin phosphorylation, matrix metalloproteinase and urokinase-plasminogen activator (uPA) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. Modulates chronic...

Wogonin

Reference: AG-CN2-0064

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Anti-inflammatory. Increases nitric oxide (NO) production [1]. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II) [2, 5]. Antioxidant [3]. Anti-viral. Shows anti-hepatitis B...

Colistin sulfate (USP Grade)

Reference: AG-CN2-0065

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Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively...

Gentamicin sulfate (USP Grade)

Reference: AG-CN2-0066

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Aminoglycoside antibiotic. Protein synthesis inhibitor. Causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site....

10Z-Hymenialdisine

Reference: AG-CN2-0067

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Insecticidal and cytotoxic [1]. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines [2, 3, 4, 9]....

Debromohymenialdisine

Reference: AG-CN2-0068

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Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1]. Cytotoxic and insecticidal [2]. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6]. Does not inhibit...

White Line Inducing Principle

Reference: AG-CN2-0069

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Lipodepsipeptide (LDP) [1]. Used as a diagnostic tool to identify tolaasin-producing bacteria pathogenic to mushrooms and responsible for brown blotch disease [1, 5]. Has haemolytic activity. Permeabilizes lipid...

Muristerone A

Reference: AG-CN2-0070

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Potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to ponasterone A (Prod. No. AG-CN2-0053 http://www.adipogen.com/ag-cn2-0053/ponasterone-a.html )....

Ecdysone

Reference: AG-CN2-0071

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Steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva...

20-Hydroxyecdysone

Reference: AG-CN2-0072

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A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of...

Makisterone A

Reference: AG-CN2-0073

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A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in...

Thiocolchicine

Reference: AG-CN2-0074

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Antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor. Axonal cytoskeleton modulator. Inhibitor of autophagosome-lysosome fusion. Apoptosis inducer. Thiocolchicine-dimers were shown to be...

Cytisine

Reference: AG-CN2-0075

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Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic,...

Thiocolchicoside

Reference: AG-CN2-0076

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Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties....

Stevioside . hydrate

Reference: AG-CN2-0077

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Noncaloric natural sweetener, 300 times more potent than sucrose [1]. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression....

Puromycin . dihydrochloride

Reference: AG-CN2-0078

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Aminonucleoside antibiotic. Protein synthesis inhibitor. Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation. Translational inhibitor in...

Cyclosporin A

Reference: AG-CN2-0079

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Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase...

Asiaticoside

Reference: AG-CN2-0080

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Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and...

4alpha-Phorbol 12-myristate 13-acetate

Reference: AG-CN2-0082

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Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6]. Might be a reasonable PKC-independent TRPV4 channels agonist [5].

Pseudolaric acid B

Reference: AG-CN2-0083

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Antifungal and antifertility compound [1, 3]. Antitumor compound [2, 7-9, 13]. PPARalpha signaling agonist [4]. Angiogenesis inhibitor [5, 6, 11]. Apoptosis and autophagy inducer [7, 9, 15, 17]....

Imperatorin

Reference: AG-CN2-0084

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Anticancer compound [1, 2, 10, 14]. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle [1, 2, 14]. HIV-1 replication inhibitor [3]. Anti-inflammatory [4, 9, 11]. Vasodilatation inducer...

Umbellulone

Reference: AG-CN2-0085

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Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which...

Piceatannol

Reference: AG-CN2-0086

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Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K [1-3, 9, 14, 15]. Inhibits the tyrosine phosphorylation of STAT3 and STAT5 [4]. Potent...

Apicidin

Reference: AG-CN2-0087

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Antiprotozoal [1]. Potent inhibitor of histone deacetylase (HDAC) [1,2]. Inhibits proliferation [2,3]. Induces cell cycle arrest at the G1 phase [2]. Induces hyperacetylation of histone H4 [5]. Apoptosis inducer...

Psammaplin A

Reference: AG-CN2-0088

€0.00 (tax incl.)

Antibiotic [1]. Caffeine-like Ca2+ releaser in heavy sarcoplasmic reticulum (HSR) [2]. Antifungal [3]. Chitinase inhibitor [3]. DNA methyltransferase inhibitor [4]. Histone deacetylase (HDAC) inhibitor [4, 5]....

Forskolin

Reference: AG-CN2-0089

€0.00 (tax incl.)

Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6]. Widely used tool to investigate cAMP as a second messenger [15]. Inotropic and antihypertensive. Smooth muscle...

Xanthorrhizol

Reference: AG-CN2-0090

€0.00 (tax incl.)

Shows calcium-antagonistic and vasorelaxant activity [1,3]. Antibacterial [2]. Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor [4,5,9]. Hepatoprotective [5, 6]. Anticancer compound....

Heliquinomycin

Reference: AG-CN2-0091

€0.00 (tax incl.)

Antibiotic [1]. DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4]. Topoisomerase I and II inhibitor (weaker than DNA helicase) [2]. DNA...

Category: Reagents

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