Ilimaquinone

Cytoplasmic microtubule inhibitor [2, 6]. Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound [1, 11]. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures [2, 6]. Blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane [3, 6]. Blocks protein transport to the plasma membrane and inhibits gap junctional communication [2, 3, 9]. HIV-1 inhibitor [4]. Blocks the cytotoxicity of ricin and diphtheria toxin [5]. S-Adenosylhomocysteinase hydrolase inhibitor and cellular methylations inhibitor [7, 12]. DNA polymerase beta lyase activity inhibitor [8]. Anti-cancer compound. [10].