Piceatannol

Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K [1-3, 9, 14, 15]. Inhibits the tyrosine phosphorylation of STAT3 and STAT5 [4]. Potent apoptosis inducer [5]. Potent anticancer compound [6, 10, 16, 17]. Suppresses NF-kB activation through IkBalpha kinase inhibition [7]. Activator of human deacetylase SIRT1 (sirtuin 1) [8]. Potent antioxidant with anti-proliferative, anti-inflammatory and cardioprotective properties [10, 14, 15, 17, 19]. Neuoprotective [11, 14]. Adipogenesis inhibitor [18]. Promotes glucose uptake, AMPK phosphorylation and GLUT4 translocation [20]. Autophagy inducer [21]