Forskolin

Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6]. Widely used tool to investigate cAMP as a second messenger [15]. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator [3, 4, 6]. Glucose transporter inhibitor [4]. Platelet aggregation inhibitor [3, 10]. Stimulates lipolysis in fat cells [8]. Non-competitive nicotinic acetylcholine receptors inhibitor [9]. MAP kinase inhibitor [11]. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue [12]. Autophagy inhibitor [13]. Hedgehog signaling inhibitor [14]. Has antiglaucoma potential [16]. Promotes neuronal differentiation of NSCs [17]. Anti-neuroinflammatory and neuroprotective agent. Ameliorated Alzheimer’s disease symptoms, restoring impairment in nesting ability and sociability, and reducing neuroinflammation and amyloid beta deposition [18].