Wortmannin

Antibiotic [1]. Potent anti-neutrophil agent with cardioprotective effects [1, 13]. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations [2, 5, 14]. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K) [3, 4]. Similar potency in vitro for the class I, II, and III PI3K. Antitumor compound. [6] Radiosensitizing agent [8]. Adipogenesis inhibitor [5, 7]. Angiogenesis inhibitor. [10] Autophagy inhibitor, regardless of the nutrient status and thus is a more suitable autophagy inhibitor than 3-MA [12,18]. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor [8, 9, 14]. Potentiates the LPS-induced nitric oxide (NO) production from macrophages [11]. Induces in vivo Alzheimer-like hyperphosphorylation in tau [15]. Polo-like kinase family inhibitor [16]. TRAIL sensitizer [19]