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Reference: PTM-7402
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Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus,
and as a vesicle thether that facilitates vesicle fusion to the Golgi...
Reference: PTM-7404
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The MRGX protein is a component of the NuA4 histone acetyltransferase complex. It alters the interaction between nucleosomes and DNA by
acetylating histones H4 and H2A, thereby facilitating the interaction between...
Reference: PTM-7407
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DNA topoisomerases I and II are a class of nucleases, with type II including two highly homologous isozymes: topoisomerase IIα and IIβ.
These enzymes are capable of regulating the topological structure of DNA,...
Reference: PTM-7423
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β-Catenin is a key downstream effector in the Wnt signaling pathway, and it is involved in early embryonic development and tumor
formation. CK1 phosphorylates β-Catenin at the Ser45 site, which triggers subsequent...
Reference: PTM-7424
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CRTC1, also known as MECT1, TORC1, and WAMTP1, is a member of the TORC family. It acts as a transcriptional coactivator for the
transcription factor CREB1 (cAMP response element binding protein), promoting...
Reference: PTM-7426
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Pyruvate dehydrogenase kinase isoform4 (PDK4) is also named as PDHK4 and belongs to the PDK/BCKDK protein kinase family. It is
upregulated by starvation in many tissues of the body during starvation. This causes...
Reference: PTM-7429
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Cardiac troponin is composed of three subunits, namely cardiac troponin T (cTnT), cardiac troponin I (cTnI), and cardiac troponin C (cTnC).
They collectively participate in the regulation of cardiac muscle...
Reference: PTM-7435
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Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures, termed as “histone
code”. The PTMs on histone including acetylation, methylation, phosphorylation...
Reference: PTM-7436
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Cathepsin K (CTSK) is a crucial member of the tissue protease family and falls under the category of cysteine proteases. Initially, it is
synthesized as an inactive form called procathepsin K and undergoes further...
Reference: PTM-7445
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PBX1, also named as Pre-B-cell leukemia transcription factor 1, which belongs to the TALE/PBX homeobox family.PBX1 acts as a
transcriptional activator of PF4 in complex with MEIS1. Isoform PBX1b as part of a...
Reference: PTM-7448
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The DNMT3 family consists of two active methyltransferases, DNMT3A and DNMT3B, along with a DNMT3-like protein known as DNMT3L.
DNMT3B plays a crucial role in regulating specific DNA methylation patterns, particularly...
Reference: PTM-7454
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TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration
with TFIIB.
Reference: PTM-7455
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Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by
recruiting epigenetic chromatin modifiers. Plays a key role in gene...
Reference: PTM-7456
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TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration
with TFIIB.
Reference: PTM-7458
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on
Background Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC
oncogenic activities. Also interacts with MXD1-MAX heterodimers to...
Reference: PTM-7460
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This is a nuclear hormone receptor, serving as a transcription factor that facilitates the effects of vitamin D3 by regulating the expression of hormone-sensitive genes. It controls the transcription of these genes by...
Reference: PTM-7468
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Eukaryotic initiation factor 4A (eIF4A) has an essential role in the binding of mRNA to the 43S preinitiation complex when protein synthesis
begins, as eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs...
Reference: PTM-7469
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Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA
replication initiation and elongation in eukaryotic cells. Core component of...
Reference: PTM-7470
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Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48, also known as RBBP7 and RBBP4), were first identified in human
cells as proteins that bind to retinoblastoma (Rb) tumor suppressor proteins. Since then,...
Reference: PTM-7471
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NELF-B is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA
polymerase II. The NELF complex causes transcriptional pausing and is counteracted by...
Reference: PTM-7472
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Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic...
Reference: PTM-7473
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CSDE1 is a highly conserved RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding
proteins in the cytoplasmic deadenylation/translational and decay interplay of the...
Reference: PTM-7475
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PARP2, also named as ADPRT2 and ADPRTL2, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADPribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and...
Reference: PTM-7476
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As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form
during DNA replication or upon DNA stress. It prevents their reannealing and in...