Quote Anti-DNMT3B Rabbit mAb
The DNMT3 family consists of two active methyltransferases, DNMT3A and DNMT3B, along with a DNMT3-like protein known as DNMT3L.
DNMT3B plays a crucial role in regulating specific DNA methylation patterns, particularly during de novo methylation. It may function as a
transcriptional corepressor by associating with CBX4 independently of DNA methylation. Mutations in the DNMT3B gene lead to
Immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
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Reference:
PTM-7448
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