Category: Reagents

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Hymeglusin Hymeglusin

Hymeglusin

Reference: 11899-2,5
€0.00 (tax incl.)
A fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme; targets cell walls of pathogens such as S. aureus in a mouse sepsis model...
(–)-Chaetominine (–)-Chaetominine

(–)-Chaetominine

Reference: 13135-2,5
€0.00 (tax incl.)
A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively); induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing...
Ikarugamycin Ikarugamycin

Ikarugamycin

Reference: 15386-2,5
€0.00 (tax incl.)
A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in...
Cercosporamide Cercosporamide

Cercosporamide

Reference: 15500-2,5
€0.00 (tax incl.)
A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2...
Herbimycin A Herbimycin A

Herbimycin A

Reference: 15504-2,5
€0.00 (tax incl.)
A benzoquinone ansamycin antibiotic that acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and Hsp90; inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src,...
A-54556B A-54556B

A-54556B

Reference: 17090-2,5
€0.00 (tax incl.)
A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus; is also effective against many strains of anaerobic bacteria
Enopeptin A Enopeptin A

Enopeptin A

Reference: 17092-2,5
€0.00 (tax incl.)
A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain; effective against Gram-positive bacteria, including methicillin-resistant S....
Micrococcin P1 Micrococcin P1

Micrococcin P1

Reference: 17093-2,5
€0.00 (tax incl.)
A macrocyclic peptide antibiotic that prevents the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria
Pyridomycin Pyridomycin

Pyridomycin

Reference: 17095-2,5
€0.00 (tax incl.)
A structurally unusual antibiotic that inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63...
Avermectin B1b Avermectin B1b

Avermectin B1b

Reference: 17453-2,5
€0.00 (tax incl.)
A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants
Enniatin A Enniatin A

Enniatin A

Reference: 17456-2,5
€0.00 (tax incl.)
One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC50 = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T....
Amidepsine A Amidepsine A

Amidepsine A

Reference: 17774-2,5
€0.00 (tax incl.)
A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 10.2 and 15.5 µM in rat liver microsomes and Raji cells, respectively
Amidepsine D Amidepsine D

Amidepsine D

Reference: 17775-2,5
€0.00 (tax incl.)
A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 17.5 and 2.8 µM in rat liver microsomes and Raji cells, respectively)
Rebeccamycin Rebeccamycin

Rebeccamycin

Reference: 17914-2,5
€0.00 (tax incl.)
An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s...
Thielavin B Thielavin B

Thielavin B

Reference: 18770-2,5
€0.00 (tax incl.)
A fungal metabolite that inhibits cyclooxygenase, blocking both the conversion of AA to PGH2 and the conversion of PGH2 to PGE2 (IC50s = 40 and 9 µM, respectively); also inhibits the reverse transcriptase of avian...
Antimycin A1 Antimycin A1

Antimycin A1

Reference: 19433-2,5
€0.00 (tax incl.)
An antibiotic that inhibits complex III of the mitochondrial ETC, preventing electron transport between cytochromes b and c, which results in the production of superoxide and eventual cell death; inhibits Bcl-2 and...
Ascochlorin Ascochlorin

Ascochlorin

Reference: 19437-2,5
€0.00 (tax incl.)
An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing...
Bischloroanthrabenzoxocinone Bischloroanthrabenzoxocinone

Bischloroanthrabenzoxocinone

Reference: 19439-2,5
€0.00 (tax incl.)
An inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 µg/ml, respectively; inhibits the growth of S. aureus and premeable E. coli strains with MICs ranging...
Cochlioquinone A Cochlioquinone A

Cochlioquinone A

Reference: 19440-2,5
€0.00 (tax incl.)
An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC50 = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC50 = 3 µM); binds to human CCR5 chemokine receptors with an IC50 value of 11 µM
Kibdelone B Kibdelone B

Kibdelone B

Reference: 19444-2,5
€0.00 (tax incl.)
A kibdelone whose mode of action and pharmacology have not been studied
Kigamicin C Kigamicin C

Kigamicin C

Reference: 19445-2,5
€0.00 (tax incl.)
Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media
RK-682 (calcium salt) RK-682 (calcium salt)

RK-682 (calcium salt)

Reference: 19450-2,5
€0.00 (tax incl.)
An inhibitor of the PTPs that blocks phosphorylation of CD45 and VHR (IC50s = 54 and 2 µM, respectively) and arrests cell cycle progress at the G1/S transition; also inhibits heparanase (IC50 = 17 µM), an...
Asukamycin Asukamycin

Asukamycin

Reference: 20133-2,5
€0.00 (tax incl.)
An antibiotic that inhibits growth in various tumor cell lines (IC50s = 1-5 µM) by activating caspases 8 and 3
Oligomycin D Oligomycin D

Oligomycin D

Reference: 20184-2,5
€0.00 (tax incl.)
A macrolide antibiotic that inhibits the mitochondrial F1FOATPase; inhibits K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cyctoxic to SW620 colon cancer cells with an IC50 value...
Trichostatin C Trichostatin C

Trichostatin C

Reference: 20220-2,5
€0.00 (tax incl.)
A glycosylated derivative of trichostatin A that has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations...
Lydicamycin Lydicamycin

Lydicamycin

Reference: 20584-2,5
€0.00 (tax incl.)
An antibiotic that is particularly cytotoxic against S. aureus, including the methicillin resistant 535 strain (MICs = 3.1-6.2 µg/ml)
Kijanimicin Kijanimicin

Kijanimicin

Reference: 20586-2,5
€0.00 (tax incl.)
An antibiotic active against a broad spectrum of microorganisms in vitro including P. acnes (MIC = 0.86 µg/ml), B. subtilis (MIC Enterobacter sp. (MIC = 64 µg/ml), Trichophyton sp. (MIC = 17.5 µg/ml), and Microsporum...
Fusarisetin A Fusarisetin A

Fusarisetin A

Reference: 20692-2,5
€0.00 (tax incl.)
A fungal metabolite that inhibits acinar morphogenesis, cell migration, and invasion in a 3D-matrigel assay system designed to study tumor cell motility
Conglobatin Conglobatin

Conglobatin

Reference: 21766-2,5
€0.00 (tax incl.)
An Hsp90 inhibitor; disrupts Hsp90 and Cdc37 binding; inhibits cell proliferation in HER2+ breast cancer cells (IC50 = 12.9-61.5 µM, respectively); decreases the number of invasive cells in vitro; inhibits cell...
Thielavin A Thielavin A

Thielavin A

Reference: 21767-2,5
€0.00 (tax incl.)
A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits...
Antimycin A4 Antimycin A4

Antimycin A4

Reference: 21999-2,5
€0.00 (tax incl.)
A component of the antimycin A antibiotic complex; more polar than antimycins A1, A2, and A3; inhibits ATP-citrate lyase with a Ki value of 64.8 µM
Bassianolide Bassianolide

Bassianolide

Reference: 22001-2,5
€0.00 (tax incl.)
A cyclodepsipeptide insecticide; synthesized by B. bassiana and V. lecanii; induces atony in B. mori when given orally at concentrations as low as 4 ppm; inhibits the muscarinic, but not nicotinic, receptor-induced...
Spirolaxine Spirolaxine

Spirolaxine

Reference: 22063-2,5
€0.00 (tax incl.)
A phthalide antibacterial agent; strong anti-H. pylori effect (MIC = 0.2 µg/cm3); 1-40 µM inhibits LoVo and HL-60 cell proliferation
PF-1163B PF-1163B

PF-1163B

Reference: 22066-2,5
€0.00 (tax incl.)
A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 µg/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans...
Duclauxin Duclauxin

Duclauxin

Reference: 22068-2,5
€0.00 (tax incl.)
Citreoindole Citreoindole

Citreoindole

Reference: 22069-2,5
€0.00 (tax incl.)
A diketopiperazine metabolite from P. citreovirde; cytotoxic against HeLa cells at 8.4 μM
Psoromic Acid Psoromic Acid

Psoromic Acid

Reference: 22168-2,5
€0.00 (tax incl.)
An inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum FAS-II; cytotoxic to U87MG and KB cancerous cell lines (IC50s = 79.40 and 56.22 mg/L, respectively); active against Plasmodium species...
Stachybotrylactam Stachybotrylactam

Stachybotrylactam

Reference: 22584-2,5
€0.00 (tax incl.)
A mycotoxin with antiviral activity; it inhibits HIV-1 protease in vitro (IC50 = 161 μM); no observable cytotoxicity at concentrations up to 100 μM in HepG2 cells,
Actinopyrone A Actinopyrone A

Actinopyrone A

Reference: 23140-2,5
€0.00 (tax incl.)
A pyrone isolated from S. pactum; selective and potent antimicrobial activity against H. pylori (MIC 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa,...
TAN 420C TAN 420C

TAN 420C

Reference: 23149-2,5
€0.00 (tax incl.)
A hydroquinone ansamycin antibiotic; inhibits B. brevis and M. flavus (MICs = 50 and 25 μg/mL, respectively); inhibits lymphocytic leukemia cell lines P388 and KB (ED50s = 0.34 and 3.49 μg/mL, respectively)
A-83016F A-83016F

A-83016F

Reference: 23240-2,5
€0.00 (tax incl.)
An aurodox antibiotic; has weak activity against S. pneumoniae PARK, S. pyogenes, and H. influenzae (MICs = 16, 32, and 64 μg/ml, respectively, in a broth dilutiion assay
Deoxyviolacein Deoxyviolacein

Deoxyviolacein

Reference: 23477-2,5
€0.00 (tax incl.)
A bacterial metabolite with anticancer properties; inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 µM; has antibacterial activity against Gram-positive...
Funalenone Funalenone

Funalenone

Reference: 23491-2,5
€0.00 (tax incl.)
A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 =...
Tetromycin B Tetromycin B

Tetromycin B

Reference: 23766-2,5
€0.00 (tax incl.)
A cysteine protease inhibitor (Kis = 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively); inhibits the growth of T. brucei in vitro (IC50 = 30.87 μM); cytotoxic to...
Ivermectin B1b Ivermectin B1b

Ivermectin B1b

Reference: 23824-2,5
€0.00 (tax incl.)
The minor component (
Saccharocarcin B Saccharocarcin B

Saccharocarcin B

Reference: 23861-2,5
€0.00 (tax incl.)
A macrocyclic lactone antibiotic; active against Gram-positive bacteria and C. trachomatis
Sporidesmolide I Sporidesmolide I

Sporidesmolide I

Reference: 23882-2,5
€0.00 (tax incl.)
A depsipeptide with no antibacterial or antifungal activity
L-156,602 L-156,602

L-156,602

Reference: 23896-2,5
€0.00 (tax incl.)
A C5a receptor antagonist (IC50 = 1.7 µg/L); an antibiotic active against Gram-positive bacteria; decreases MDP-induced inflammation in mice when administered at a dose of 0.5 mg/kg and concanavalin A-induced...
Aspochracin Aspochracin

Aspochracin

Reference: 23914-2,5
€0.00 (tax incl.)
A cyclic tripeptide with insecticidal activity; toxic to fall web worms (LD50 = 100 µg/g) and to silkworms; has no antifungal activity against C. albicans and does not have antimicrobial activity up to a concentration...
TPU-0037C TPU-0037C

TPU-0037C

Reference: 24179-2,5
€0.00 (tax incl.)
A Streptomyces metabolite; structurally similar to lydicamycin; active against Gram-positive bacteria (MICs = 0.39-3.13 µg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 µg/ml); ineffective against...
Diffractaic Acid Diffractaic Acid

Diffractaic Acid

Reference: 24208-2,5
€0.00 (tax incl.)
A lichen metabolite with diverse biological activities; cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively); inhibits growth of M. tuberculosis (MIC = 41.7 μM); reduces...
Kotanin A Kotanin A

Kotanin A

Reference: 24917-2,5
€0.00 (tax incl.)
A fungal metabolite; produced by A. glaucus (A. clavatus), A. alliaceus, and A. niger; toxic to day-old chicks (LD100 = 62.5 mg/kg)
Hydroaurantiogliocladin Hydroaurantiogliocladin

Hydroaurantiogliocladin

Reference: 24920-2,5
€0.00 (tax incl.)
A fungal metabolite; the hydroquinone form of aurantiogliocladin
Folipastatin Folipastatin

Folipastatin

Reference: 24924-2,5
€0.00 (tax incl.)
An inhibitor of PLA2 ( IC50 = 39 μM); inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM); inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50...
Stictic Acid Stictic Acid

Stictic Acid

Reference: 25017-2,5
€0.00 (tax incl.)
A depsidone that preferentially inhibits growth of HT-29 human colon adenocarcinoma cells over non-malignant cells (IC50s = 29.29 and 2,478.4 µg/ml, respectively)
Isokotanin B Isokotanin B

Isokotanin B

Reference: 25082-2,5
€0.00 (tax incl.)
A fungal metabolite; dietary administration reduces C. hemipterus larvae feeding by 21% at 100 ppm
Aspochalasin M Aspochalasin M

Aspochalasin M

Reference: 25087-2,5
€0.00 (tax incl.)
A fungal metabolite; inhibits the growth of HL-60 cells (IC50 = 20 µM)
Petromurin C Petromurin C

Petromurin C

Reference: 25089-2,5
€0.00 (tax incl.)
A fungal metabolite; cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml); has activity against T. foetus in vitro (IC50 = 100 μg/ml)
Unguisin B Unguisin B

Unguisin B

Reference: 25115-2,5
€0.00 (tax incl.)
A cyclic heptapeptide containing GABA
Cochlioquinone B Cochlioquinone B

Cochlioquinone B

Reference: 25121-2,5
€0.00 (tax incl.)
A fungal metabolite; inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, at 100 ppm; inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone...
Lobaric Acid Lobaric Acid

Lobaric Acid

Reference: 25205-2,5
€0.00 (tax incl.)
A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer...
Acetylaszonalenin Acetylaszonalenin

Acetylaszonalenin

Reference: 25207-2,5
€0.00 (tax incl.)
A fungal metabolite; NK1 antagonist (Ki = 170 μM)
Palitantin Palitantin

Palitantin

Reference: 25208-2,5
€0.00 (tax incl.)
A fungal metabolite; inhibits HIV-1 integrase (IC50s = 350 and 268 µM for 3’-processing and strand transfer activity, respectively); has been used as a standard for dereplication of natural products
Leucanicidin Leucanicidin

Leucanicidin

Reference: 25479-2,5
€0.00 (tax incl.)
A macrolide bacterial metabolite; toxic to L. separata fourth instar larvae at 20 ppm; toxic to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 µg/ml)
Setosusin Setosusin

Setosusin

Reference: 25484-2,5
€0.00 (tax incl.)
A fungal metabolite; reduces Aβ aggregate-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM); induces tremors in mice at 30 mg/kg
Herbimycin C Herbimycin C

Herbimycin C

Reference: 25485-2,5
€0.00 (tax incl.)
A bacterial metabolite; cytotoxic to HeLa and Ehrlich cells (IC50s = 7.3 and 1.2 μg/ml, respectively)
Berninamycin D Berninamycin D

Berninamycin D

Reference: 25513-2,5
€0.00 (tax incl.)
A cyclic thiopeptide fungal metabolite
Luteoreticulin Luteoreticulin

Luteoreticulin

Reference: 25515-2,5
€0.00 (tax incl.)
A nitro-containing bacterial metabolite; has mosquitocidal activity against A. aegypti at 6.25 mg/L; has nematocidal activity against C. elegans
Pestalotin Pestalotin

Pestalotin

Reference: 25516-2,5
€0.00 (tax incl.)
A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3...
Filipin II Filipin II

Filipin II

Reference: 25521-2,5
€0.00 (tax incl.)
An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a...
Sporidesmolide V Sporidesmolide V

Sporidesmolide V

Reference: 25531-2,5
€0.00 (tax incl.)
A cyclodepsipeptide fungal metabolite
TPU-0037A TPU-0037A

TPU-0037A

Reference: 25761-2,5
€0.00 (tax incl.)
An antibiotic; inhibits the growth of Gram-positive bacteria, including MRSA, B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml)
Gilvocarcin M Gilvocarcin M

Gilvocarcin M

Reference: 25762-2,5
€0.00 (tax incl.)
An antibiotic; active against S. aureus bacteria at 32 µg/ml; inhibits growth of KB cells (IC50 = 0.52 µg/ml); intercalates into bacteriophage PM2 DNA; toxic to rats (LD50 = 450 mg/kg, i.v.)
Ajoene Ajoene

Ajoene

Reference: 26242-2,5
€0.00 (tax incl.)
A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma...
Lachnone A Lachnone A

Lachnone A

Reference: 26462-2,5
€0.00 (tax incl.)
A fungal metabolite; inactive against P. falciparum, C. albicans, and M. tuberculosis; not cytotoxic to KB or BC-1 cells
7-hydroxy Pestalotin 7-hydroxy Pestalotin

7-hydroxy Pestalotin

Reference: 26523-2,5
€0.00 (tax incl.)
A fungal metabolite; phytotoxic against a variety of plants
Febuxostat Acyl Glucuronide Febuxostat Acyl Glucuronide

Febuxostat Acyl Glucuronide

Reference: 26599-2,5
€0.00 (tax incl.)
A metabolite of febuxostat; is formed via glucuronidation of febuxostat by UGTs
Paraherquamide E Paraherquamide E

Paraherquamide E

Reference: 26680-2,5
€0.00 (tax incl.)
A fungal metabolite with anthelmintic and insecticidal activities; lethal to C. elegans (LD50 = 6 μg/ml); lethal to O. fasciatus (LD50 = 0.089 μg/nymph); oral administration reduces T. colubriformis fecal egg count in...
Thiocillin I Thiocillin I

Thiocillin I

Reference: 26681-2,5
€0.00 (tax incl.)
An antibiotic originally isolated from Bacillus; has activity against Gram-positive, but not Gram-negative, bacteria; inhibits the growth of B. subtilis, B. anthracis, S. aureus, S. pyogenes, and S. pneumoniae strains...
Quadrone Quadrone

Quadrone

Reference: 26688-2,5
€0.00 (tax incl.)
A sesquiterpene originally isolated from A. terreus; cytotoxic to human carcinoma KB cells in vitro (EC50 = 1.3 μg/ml)
L-681,217 L-681,217

L-681,217

Reference: 26689-2,5
€0.00 (tax incl.)
An antibiotic; active against Gram positive and Gram negative bacteria at 255 µg/ml; inhibits bacterial protein synthesis (EC50 = 0.4 µM in E. coli); increases EF-Tu-associated GTPase activity (EC50 = 6 µM in E. coli)
Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Reference: 27107-2,5
€0.00 (tax incl.)
A synthetic Aβ peptide that lacks 14 C-terminal amino acids; more soluble than Aβ42; forms fibrils and plaques in vitro that are similar to those formed by Aβ42; induces learning deficits in a passive avoidance task...
Ac-VDVAD-pNA (trifluoroacetate salt) Ac-VDVAD-pNA (trifluoroacetate salt)

Ac-VDVAD-pNA (trifluoroacetate salt)

Reference: 27134-2,5
€0.00 (tax incl.)
A colorimetric caspase-2 substrate; cleavage of the VDVAD peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of caspase-2 activity; can also be cleaved, with lower...
ACTH (18-39) (human) ACTH (18-39) (human)

ACTH (18-39) (human)

Reference: 27274-2,5
€0.00 (tax incl.)
A C-terminal peptide fragment of ACTH; produced via processing of ACTH in the intermediate lobe of the pituitary gland; increases cumulative food intake in fasted, but not fed, rats at 2.5 nmol/animal,...
4-hydroxy Valsartan 4-hydroxy Valsartan

4-hydroxy Valsartan

Reference: 27849-2,5
€0.00 (tax incl.)
A major metabolite of valsartan; reduces epinephrine and collagen-induced platelet aggregation in human whole blood
Saroglitazar Saroglitazar

Saroglitazar

Reference: 27851-2,5
€0.00 (tax incl.)
A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin...
Spinosyn D aglycone Spinosyn D aglycone

Spinosyn D aglycone

Reference: 27937-2,5
€0.00 (tax incl.)
An aglycone form of spinosyn D; not lethal to H. virescens (tobacco budworm) neonate larvae (LC50 = >64 ppm)
TAN 1364B TAN 1364B

TAN 1364B

Reference: 27964-2,5
€0.00 (tax incl.)
A PTP inhibitor; inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively)
3'-Ethoxy Spinosyn L 17-pseudoaglycone 3'-Ethoxy Spinosyn L 17-pseudoaglycone

3'-Ethoxy Spinosyn L 17-pseudoaglycone

Reference: 27965-2,5
€0.00 (tax incl.)
An acid degradation product of 3’-ethoxy-5,6-dihydrospinosyn L; has no insecticidal activity against the tobacco budworm up to 64 ppm
Spinosyn D 17-pseudoaglycone Spinosyn D 17-pseudoaglycone

Spinosyn D 17-pseudoaglycone

Reference: 27975-2,5
€0.00 (tax incl.)
A hydrolysis product of spinosyn D; not lethal to tobacco budworms (H. virescens) at concentrations up to 64 ppm
Sultriecin Sultriecin

Sultriecin

Reference: 27976-2,5
€0.00 (tax incl.)
A fungal metabolite; active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml); cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml,...
Deacetylravidomycin Deacetylravidomycin

Deacetylravidomycin

Reference: 27991-2,5
€0.00 (tax incl.)
A microbial metabolite with light-dependent antibiotic and anticancer activities; active against Gram-positive bacteria including B. subtilis, S. aureus, S. epidermidis, and E. faecalis (MICs = 0.78-1.56 and
Eprinomectin B1b Eprinomectin B1b

Eprinomectin B1b

Reference: 27994-2,5
€0.00 (tax incl.)
A minor component of eprinomectin
10'-Desmethoxystreptonigrin 10'-Desmethoxystreptonigrin

10'-Desmethoxystreptonigrin

Reference: 28065-2,5
€0.00 (tax incl.)
An antibiotic; active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively); cytotoxic to HCT116 colon and...
Neoaureothin Neoaureothin

Neoaureothin

Reference: 28091-2,5
€0.00 (tax incl.)
A bacterial metabolite; an AR antagonist that inhibits binding of DHT to ARs (IC50 = 13 μM); inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM); is cytotoxic to A549, HCT116,...
SCH 38519 SCH 38519

SCH 38519

Reference: 28092-2,5
€0.00 (tax incl.)
A fungal metabolite; inhibits thrombin-induced aggregation, as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 µg/ml, respectively); inhibits the growth of various Gram-negative and...

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