Quote RK-682 (calcium salt)
An inhibitor of the PTPs that blocks phosphorylation of CD45 and VHR (IC50s = 54 and 2 µM, respectively) and arrests cell cycle progress at the G1/S transition; also inhibits heparanase (IC50 = 17 µM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis
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Reference:
19450-2,5
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