Quote 10'-Desmethoxystreptonigrin
An antibiotic; active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively); cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively); cytotoxic to etoposide- and teniposide-resistant HCT116 cells and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively); an inhibitor of p21ras farnesylation (IC50 = 21 nM)
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Reference:
28065-2,5
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