Quote Herbimycin A
A benzoquinone ansamycin antibiotic that acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and Hsp90; inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB; binds Hsp90 and destabilizes client proteins, including Src, Bcr-Abl, and ErbB2
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Reference:
15504-2,5
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