Ajoene

A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma cells (IC50 = 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM); reduces tumor growth in a B16/BL6 mouse model of melanoma at 25 µg/kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at 1-25 µg/g; inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets at 75-100 µg/ml and in platelet-rich plasma isolated from baboons at 25 mg/kg; prevents thrombus formation on damaged arterial walls in heparinized pigs in an in situ model of thrombogenesis at 25 mg/kg; reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, TBARS formation, and protein oxidation in a mouse model of NAFLD