Stictic Acid Reference: 25017-2,5 A depsidone that preferentially inhibits growth of HT-29 human colon adenocarcinoma cells over non-malignant cells (IC50s = 29.29 and 2,478.4 µg/ml, respectively)
Isokotanin B Reference: 25082-2,5 A fungal metabolite; dietary administration reduces C. hemipterus larvae feeding by 21% at 100 ppm
Aspochalasin M Reference: 25087-2,5 A fungal metabolite; inhibits the growth of HL-60 cells (IC50 = 20 µM)
Petromurin C Reference: 25089-2,5 A fungal metabolite; cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml); has activity against T. foetus in vitro (IC50 = 100 μg/ml)
Cochlioquinone B Reference: 25121-2,5 A fungal metabolite; inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, at 100 ppm; inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria,
Lobaric Acid Reference: 25205-2,5 A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml); inhibits PTP1B (IC50 = 0.87 μM); inhibits 12(S)-HETE production by 12(S)-lipoxygenase (IC50 = 28.5 μM); decreases lesion number, but not lesion diameter, in TMV-infected tobacco leaves (250 μM),
Palitantin Reference: 25208-2,5 A fungal metabolite; inhibits HIV-1 integrase (IC50s = 350 and 268 µM for 3’-processing and strand transfer activity, respectively); has been used as a standard for dereplication of natural products
Leucanicidin Reference: 25479-2,5 A macrolide bacterial metabolite; toxic to L. separata fourth instar larvae at 20 ppm; toxic to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 µg/ml)
Setosusin Reference: 25484-2,5 A fungal metabolite; reduces Aβ aggregate-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM); induces tremors in mice at 30 mg/kg
Herbimycin C Reference: 25485-2,5 A bacterial metabolite; cytotoxic to HeLa and Ehrlich cells (IC50s = 7.3 and 1.2 μg/ml, respectively)