Luteoreticulin Reference: 25515-2,5 A nitro-containing bacterial metabolite; has mosquitocidal activity against A. aegypti at 6.25 mg/L; has nematocidal activity against C. elegans
Pestalotin Reference: 25516-2,5 A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3 from 30-500 mg/L; reduces growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 12.5, 50, 50, and 50 μg/ml, respectively); cytotoxic to HL-60, MKN45, LoVo, and A549 cells (IC50s = 64.87-182.92 μM); has been used as a standard for dereplication of natural products
Filipin II Reference: 25521-2,5 An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml),
TPU-0037A Reference: 25761-2,5 An antibiotic; inhibits the growth of Gram-positive bacteria, including MRSA, B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml)
Gilvocarcin M Reference: 25762-2,5 An antibiotic; active against S. aureus bacteria at 32 µg/ml; inhibits growth of KB cells (IC50 = 0.52 µg/ml); intercalates into bacteriophage PM2 DNA; toxic to rats (LD50 = 450 mg/kg, i.v.)
Ajoene Reference: 26242-2,5 A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma cells (IC50 = 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM); reduces tumor growth in a B16/BL6 mouse model of melanoma at 25 µg/kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at 1-25 µg/g; inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets at 75-100 µg/ml and in platelet-rich plasma isolated from baboons at 25 mg/kg; prevents thrombus formation on damaged arterial walls in heparinized pigs in an in situ model of thrombogenesis at 25 mg/kg; reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, TBARS formation, and protein oxidation in a mouse model of NAFLD
Lachnone A Reference: 26462-2,5 A fungal metabolite; inactive against P. falciparum, C. albicans, and M. tuberculosis; not cytotoxic to KB or BC-1 cells
7-hydroxy Pestalotin Reference: 26523-2,5 A fungal metabolite; phytotoxic against a variety of plants
Febuxostat Acyl Glucuronide Reference: 26599-2,5 A metabolite of febuxostat; is formed via glucuronidation of febuxostat by UGTs