Lobaric Acid

A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml); inhibits PTP1B (IC50 = 0.87 μM); inhibits 12(S)-HETE production by 12(S)-lipoxygenase (IC50 = 28.5 μM); decreases lesion number, but not lesion diameter, in TMV-infected tobacco leaves (250 μM),