Tetromycin B Reference: 23766-2,5 A cysteine protease inhibitor (Kis = 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively); inhibits the growth of T. brucei in vitro (IC50 = 30.87 μM); cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s = 71.77 and 20.2 μM, respectively)
Ivermectin B1b Reference: 23824-2,5 The minor component (<20%) of ivermectin; binds to glutamate-gated chloride channels, inducing irreversible channel opening; ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells ,
Saccharocarcin B Reference: 23861-2,5 A macrocyclic lactone antibiotic; active against Gram-positive bacteria and C. trachomatis
L-156,602 Reference: 23896-2,5 A C5a receptor antagonist (IC50 = 1.7 µg/L); an antibiotic active against Gram-positive bacteria; decreases MDP-induced inflammation in mice when administered at a dose of 0.5 mg/kg and concanavalin A-induced inflammation at doses of 0.25 and 0.5 mg/kg
Aspochracin Reference: 23914-2,5 A cyclic tripeptide with insecticidal activity; toxic to fall web worms (LD50 = 100 µg/g) and to silkworms; has no antifungal activity against C. albicans and does not have antimicrobial activity up to a concentration of 0.1 mg/ml
TPU-0037C Reference: 24179-2,5 A Streptomyces metabolite; structurally similar to lydicamycin; active against Gram-positive bacteria (MICs = 0.39-3.13 µg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 µg/ml); ineffective against Gram-negative bacteria (MICs = >50 µg/ml)
Diffractaic Acid Reference: 24208-2,5 A lichen metabolite with diverse biological activities; cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively); inhibits growth of M. tuberculosis (MIC = 41.7 μM); reduces indomethacin-induced neutrophil infiltration, lipid peroxidation, MPx activity, and the number of gastric lesions as well as reverses decreases in SOD and GPx activities in rat gastric mucosa from 25-200 mg/kg; reduces acetic acid-induced writhing and increases the pressure pain threshold in mice
Kotanin A Reference: 24917-2,5 A fungal metabolite; produced by A. glaucus (A. clavatus), A. alliaceus, and A. niger; toxic to day-old chicks (LD100 = 62.5 mg/kg)
Hydroaurantiogliocladin Reference: 24920-2,5 A fungal metabolite; the hydroquinone form of aurantiogliocladin
Folipastatin Reference: 24924-2,5 An inhibitor of PLA2 ( IC50 = 39 μM); inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM); inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50 = 0.39 μM)