Bassianolide Reference: 22001-2,5 A cyclodepsipeptide insecticide; synthesized by B. bassiana and V. lecanii; induces atony in B. mori when given orally at concentrations as low as 4 ppm; inhibits the muscarinic, but not nicotinic, receptor-induced contractions in response to acetylcholine in smooth muscle
Spirolaxine Reference: 22063-2,5 A phthalide antibacterial agent; strong anti-H. pylori effect (MIC = 0.2 µg/cm3); 1-40 µM inhibits LoVo and HL-60 cell proliferation
PF-1163B Reference: 22066-2,5 A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 µg/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans (MIC = 0.0016 µg/ml); hydroxy form of PF-1163A,
Citreoindole Reference: 22069-2,5 A diketopiperazine metabolite from P. citreovirde; cytotoxic against HeLa cells at 8.4 μM
Psoromic Acid Reference: 22168-2,5 An inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum FAS-II; cytotoxic to U87MG and KB cancerous cell lines (IC50s = 79.40 and 56.22 mg/L, respectively); active against Plasmodium species (IC50 = 29.2 µM against blood stage P. falciparum)
Stachybotrylactam Reference: 22584-2,5 A mycotoxin with antiviral activity; it inhibits HIV-1 protease in vitro (IC50 = 161 μM); no observable cytotoxicity at concentrations up to 100 μM in HepG2 cells,
Actinopyrone A Reference: 23140-2,5 A pyrone isolated from S. pactum; selective and potent antimicrobial activity against H. pylori (MIC 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis; intravenous administration (30 μg/kg) increases coronary blood flow in dogs by 196.2%
TAN 420C Reference: 23149-2,5 A hydroquinone ansamycin antibiotic; inhibits B. brevis and M. flavus (MICs = 50 and 25 μg/mL, respectively); inhibits lymphocytic leukemia cell lines P388 and KB (ED50s = 0.34 and 3.49 μg/mL, respectively)
A-83016F Reference: 23240-2,5 An aurodox antibiotic; has weak activity against S. pneumoniae PARK, S. pyogenes, and H. influenzae (MICs = 16, 32, and 64 μg/ml, respectively, in a broth dilutiion assay
Deoxyviolacein Reference: 23477-2,5 A bacterial metabolite with anticancer properties; inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 µM; has antibacterial activity against Gram-positive bacteria when used at a concentration of 125 µg/ml; has antifungal activity when used at a concentration of 2 mg/ml
Funalenone Reference: 23491-2,5 A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 = 87 μM); selectively inhibits MMP-1 (IC50 = 170 μM) over MMP-2 and MMP-9 with 18.3% and 38.2% inhibition, respectively (400 μM); inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM); inhibits growth of S. aureus with a MIC value of 64 μg/mL