Funalenone

A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 = 87 μM); selectively inhibits MMP-1 (IC50 = 170 μM) over MMP-2 and MMP-9 with 18.3% and 38.2% inhibition, respectively (400 μM); inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM); inhibits growth of S. aureus with a MIC value of 64 μg/mL