Kibdelone B Reference: 19444-2,5 A kibdelone whose mode of action and pharmacology have not been studied
Kigamicin C Reference: 19445-2,5 Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media
RK-682 (calcium salt) Reference: 19450-2,5 An inhibitor of the PTPs that blocks phosphorylation of CD45 and VHR (IC50s = 54 and 2 µM, respectively) and arrests cell cycle progress at the G1/S transition; also inhibits heparanase (IC50 = 17 µM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis
Asukamycin Reference: 20133-2,5 An antibiotic that inhibits growth in various tumor cell lines (IC50s = 1-5 µM) by activating caspases 8 and 3
Oligomycin D Reference: 20184-2,5 A macrolide antibiotic that inhibits the mitochondrial F1FOATPase; inhibits K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cyctoxic to SW620 colon cancer cells with an IC50 value of 36 µM
Trichostatin C Reference: 20220-2,5 A glycosylated derivative of trichostatin A that has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A
Lydicamycin Reference: 20584-2,5 An antibiotic that is particularly cytotoxic against S. aureus, including the methicillin resistant 535 strain (MICs = 3.1-6.2 µg/ml)
Kijanimicin Reference: 20586-2,5 An antibiotic active against a broad spectrum of microorganisms in vitro including P. acnes (MIC = 0.86 µg/ml), B. subtilis (MIC Enterobacter sp. (MIC = 64 µg/ml), Trichophyton sp. (MIC = 17.5 µg/ml), and Microsporum sp. (MIC = 17.5 µg/ml); effective in mice against P. berghei, a protozoan parasite that causes malaria in certain rodents
Fusarisetin A Reference: 20692-2,5 A fungal metabolite that inhibits acinar morphogenesis, cell migration, and invasion in a 3D-matrigel assay system designed to study tumor cell motility
Conglobatin Reference: 21766-2,5 An Hsp90 inhibitor; disrupts Hsp90 and Cdc37 binding; inhibits cell proliferation in HER2+ breast cancer cells (IC50 = 12.9-61.5 µM, respectively); decreases the number of invasive cells in vitro; inhibits cell proliferation in KYSE510 cells with an IC50 value of 9.31 µM; inhibits β integrin ,
Thielavin A Reference: 21767-2,5 A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits α-glucosidase (IC50 = 23.8 µM; Ki = 27.8 µM)
Antimycin A4 Reference: 21999-2,5 A component of the antimycin A antibiotic complex; more polar than antimycins A1, A2, and A3; inhibits ATP-citrate lyase with a Ki value of 64.8 µM