Micrococcin P1 Reference: 17093-2,5 A macrocyclic peptide antibiotic that prevents the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria
Pyridomycin Reference: 17095-2,5 A structurally unusual antibiotic that inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml)
Avermectin B1b Reference: 17453-2,5 A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants
Enniatin A Reference: 17456-2,5 One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC50 = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa
Amidepsine A Reference: 17774-2,5 A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 10.2 and 15.5 µM in rat liver microsomes and Raji cells, respectively
Amidepsine D Reference: 17775-2,5 A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 17.5 and 2.8 µM in rat liver microsomes and Raji cells, respectively)
Rebeccamycin Reference: 17914-2,5 An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM)
Thielavin B Reference: 18770-2,5 A fungal metabolite that inhibits cyclooxygenase, blocking both the conversion of AA to PGH2 and the conversion of PGH2 to PGE2 (IC50s = 40 and 9 µM, respectively); also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity
Antimycin A1 Reference: 19433-2,5 An antibiotic that inhibits complex III of the mitochondrial ETC, preventing electron transport between cytochromes b and c, which results in the production of superoxide and eventual cell death; inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis
Ascochlorin Reference: 19437-2,5 An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through STAT3
Bischloroanthrabenzoxocinone Reference: 19439-2,5 An inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 µg/ml, respectively; inhibits the growth of S. aureus and premeable E. coli strains with MICs ranging from 0.2-0.4 µg/ml
Cochlioquinone A Reference: 19440-2,5 An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC50 = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC50 = 3 µM); binds to human CCR5 chemokine receptors with an IC50 value of 11 µM