Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) Reference: K1024-1 Inhibit proteolytic degradation during bacterium lysis and protein extraction
Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) Reference: K1024-20 Inhibit proteolytic degradation during bacterium lysis and protein extraction
Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) Reference: K1024-50 Inhibit proteolytic degradation during bacterium lysis and protein extraction
Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) Reference: K1024-100 Inhibit proteolytic degradation during bacterium lysis and protein extraction
Hymeglusin Reference: 11899-2,5 A fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme; targets cell walls of pathogens such as S. aureus in a mouse sepsis model of infection
(–)-Chaetominine Reference: 13135-2,5 A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively); induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing cytochrome C release, and activation of caspase-3 and caspase-9; decreases MRP1-mediated doxorubicin efflux and restores sensitivity to doxorubicin in resistant K562 cells
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) Reference: 13956-2,5 A ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases
Ikarugamycin Reference: 15386-2,5 A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in macrophages; inhibits clathrin-coated pit-mediated endocytosis
Cercosporamide Reference: 15500-2,5 A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells
Herbimycin A Reference: 15504-2,5 A benzoquinone ansamycin antibiotic that acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and Hsp90; inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB; binds Hsp90 and destabilizes client proteins, including Src, Bcr-Abl, and ErbB2
A-54556B Reference: 17090-2,5 A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus; is also effective against many strains of anaerobic bacteria
Enopeptin A Reference: 17092-2,5 A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain; effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 µg/ml), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs = 200 µg/ml) yet does not inhibit fungi