Category: Reagents

Reference: 21576-10
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A bicyclic monoterpene with diverse biological activities; reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains (MICs = 0.75-1.29, 1.05-1.59, and...
Reference: 21576-50
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A bicyclic monoterpene with diverse biological activities; reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains (MICs = 0.75-1.29, 1.05-1.59, and...
Reference: 21719-1
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A monocyclic monoterpene with diverse biological activities; inhibits the growth of bacteria including S. aureus, B. cereus, E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, M. catarrhalis, and C. neoformans (MICs...
Reference: 21719-5
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A monocyclic monoterpene with diverse biological activities; inhibits the growth of bacteria including S. aureus, B. cereus, E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, M. catarrhalis, and C. neoformans (MICs...
Reference: 22184-1
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A monoterpene with diverse biological activities; reduces compound action potential (CAP) peak amplitude in isolated frog sciatic nerves (IC50 = 0.51 mM); inhibits the radial growth of M. gypsum, T. vercossum, and C....
Reference: 22184-10
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A monoterpene with diverse biological activities; reduces compound action potential (CAP) peak amplitude in isolated frog sciatic nerves (IC50 = 0.51 mM); inhibits the radial growth of M. gypsum, T. vercossum, and C....
Reference: 22184-5
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A monoterpene with diverse biological activities; reduces compound action potential (CAP) peak amplitude in isolated frog sciatic nerves (IC50 = 0.51 mM); inhibits the radial growth of M. gypsum, T. vercossum, and C....
Reference: 23159-100
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A monoterpene with diverse biological activities; inhibits the growth of S. typhimurium, E. coli, L. monocytogenes, S. epidermidis, and S. aureus (MICs = 0.266-0.608% v/v); decreases the invasive activity of HT-1080...
Reference: 23161-100
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A monoterpene with diverse biological activities; antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and...
Reference: 23161-25
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A monoterpene with diverse biological activities; antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and...
Reference: 23161-250
€0.00 (tax incl.)
A monoterpene with diverse biological activities; antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and...
Reference: 23161-50
€0.00 (tax incl.)
A monoterpene with diverse biological activities; antibacterial activity against S. aureus, E. faecium, E. coli, and M. smegmatis (MICs = 0.78, 12.5, 0.78, and 1.56 μl/ml, respectively, in an agar diffusion assay) and...
Reference: 23722-100
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A monoterpene with diverse biological activities; scavenges DPPH and ABTS+ free radicals (IC50s = 2.8 and 30 mM, respectively); reduces APPH-induced hemolysis in isolated human erythrocytes; reduces the growth of T....
Reference: 23722-250
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A monoterpene with diverse biological activities; scavenges DPPH and ABTS+ free radicals (IC50s = 2.8 and 30 mM, respectively); reduces APPH-induced hemolysis in isolated human erythrocytes; reduces the growth of T....
Reference: 23722-500
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A monoterpene with diverse biological activities; scavenges DPPH and ABTS+ free radicals (IC50s = 2.8 and 30 mM, respectively); reduces APPH-induced hemolysis in isolated human erythrocytes; reduces the growth of T....
Reference: 18656-10
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An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and...
Reference: 18656-25
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An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and...
Reference: 18656-5
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An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and...
Reference: 11899-2,5
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A fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme; targets cell walls of pathogens such as S. aureus in a mouse sepsis model...
Reference: 13135-2,5
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A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively); induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing...
Reference: 15386-2,5
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A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in...
Reference: 15500-2,5
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A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2...
Reference: 15504-2,5
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A benzoquinone ansamycin antibiotic that acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and Hsp90; inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src,...
Reference: 17090-2,5
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A natural acyldepsipeptide that is effective against Gram-positive bacteria, including penicillin-resistant S. aureus; is also effective against many strains of anaerobic bacteria
Reference: 17092-2,5
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A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain; effective against Gram-positive bacteria, including methicillin-resistant S....
Reference: 17093-2,5
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A macrocyclic peptide antibiotic that prevents the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria
Reference: 17095-2,5
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A structurally unusual antibiotic that inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63...
Reference: 17453-2,5
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A minor component of avermectin broth, used broadly against nematodes, ticks, flies, and ants
Reference: 17456-2,5
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One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC50 = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T....
Reference: 17774-2,5
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A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 10.2 and 15.5 µM in rat liver microsomes and Raji cells, respectively
Reference: 17775-2,5
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A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC50s = 17.5 and 2.8 µM in rat liver microsomes and Raji cells, respectively)
Reference: 17914-2,5
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An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s...
Reference: 18770-2,5
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A fungal metabolite that inhibits cyclooxygenase, blocking both the conversion of AA to PGH2 and the conversion of PGH2 to PGE2 (IC50s = 40 and 9 µM, respectively); also inhibits the reverse transcriptase of avian...
Reference: 19433-2,5
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An antibiotic that inhibits complex III of the mitochondrial ETC, preventing electron transport between cytochromes b and c, which results in the production of superoxide and eventual cell death; inhibits Bcl-2 and...
Reference: 19437-2,5
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An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing...
Reference: 19439-2,5
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An inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 µg/ml, respectively; inhibits the growth of S. aureus and premeable E. coli strains with MICs ranging...
Reference: 19440-2,5
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An inhibitor of DGK (Ki = 3.1 µM) and DGAT (IC50 = 5.6 µM); reduces the concentration of phosphatidic acid in T cell lymphoma (IC50 = 3 µM); binds to human CCR5 chemokine receptors with an IC50 value of 11 µM
Reference: 19444-2,5
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A kibdelone whose mode of action and pharmacology have not been studied
Reference: 19445-2,5
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Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media
Reference: 19450-2,5
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An inhibitor of the PTPs that blocks phosphorylation of CD45 and VHR (IC50s = 54 and 2 µM, respectively) and arrests cell cycle progress at the G1/S transition; also inhibits heparanase (IC50 = 17 µM), an...
Reference: 20133-2,5
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An antibiotic that inhibits growth in various tumor cell lines (IC50s = 1-5 µM) by activating caspases 8 and 3
Reference: 20184-2,5
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A macrolide antibiotic that inhibits the mitochondrial F1FOATPase; inhibits K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cyctoxic to SW620 colon cancer cells with an IC50 value...
Reference: 20220-2,5
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A glycosylated derivative of trichostatin A that has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations...
Reference: 20584-2,5
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An antibiotic that is particularly cytotoxic against S. aureus, including the methicillin resistant 535 strain (MICs = 3.1-6.2 µg/ml)
Reference: 20586-2,5
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An antibiotic active against a broad spectrum of microorganisms in vitro including P. acnes (MIC = 0.86 µg/ml), B. subtilis (MIC Enterobacter sp. (MIC = 64 µg/ml), Trichophyton sp. (MIC = 17.5 µg/ml), and Microsporum...
Reference: 20692-2,5
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A fungal metabolite that inhibits acinar morphogenesis, cell migration, and invasion in a 3D-matrigel assay system designed to study tumor cell motility
Reference: 21766-2,5
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An Hsp90 inhibitor; disrupts Hsp90 and Cdc37 binding; inhibits cell proliferation in HER2+ breast cancer cells (IC50 = 12.9-61.5 µM, respectively); decreases the number of invasive cells in vitro; inhibits cell...
Reference: 21767-2,5
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A natural COX inhibitor; blocks conversion of arachidonic acid to PGH2 (IC50 = 10 µM); blocks conversion of PGH2 to PGE2 (IC50 = 40 µM); inhibits glucose-6-phosphatase (IC50 = 4.6 µM); non-competitively inhibits...
Reference: 21999-2,5
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A component of the antimycin A antibiotic complex; more polar than antimycins A1, A2, and A3; inhibits ATP-citrate lyase with a Ki value of 64.8 µM
Reference: 22001-2,5
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A cyclodepsipeptide insecticide; synthesized by B. bassiana and V. lecanii; induces atony in B. mori when given orally at concentrations as low as 4 ppm; inhibits the muscarinic, but not nicotinic, receptor-induced...
Reference: 22063-2,5
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A phthalide antibacterial agent; strong anti-H. pylori effect (MIC = 0.2 µg/cm3); 1-40 µM inhibits LoVo and HL-60 cell proliferation
Reference: 22066-2,5
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A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 µg/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans...
Reference: 22068-2,5
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Reference: 22069-2,5
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A diketopiperazine metabolite from P. citreovirde; cytotoxic against HeLa cells at 8.4 μM
Reference: 22168-2,5
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An inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum FAS-II; cytotoxic to U87MG and KB cancerous cell lines (IC50s = 79.40 and 56.22 mg/L, respectively); active against Plasmodium species...
Reference: 22584-2,5
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A mycotoxin with antiviral activity; it inhibits HIV-1 protease in vitro (IC50 = 161 μM); no observable cytotoxicity at concentrations up to 100 μM in HepG2 cells,
Reference: 23140-2,5
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A pyrone isolated from S. pactum; selective and potent antimicrobial activity against H. pylori (MIC 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa,...
Reference: 23149-2,5
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A hydroquinone ansamycin antibiotic; inhibits B. brevis and M. flavus (MICs = 50 and 25 μg/mL, respectively); inhibits lymphocytic leukemia cell lines P388 and KB (ED50s = 0.34 and 3.49 μg/mL, respectively)
Reference: 23240-2,5
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An aurodox antibiotic; has weak activity against S. pneumoniae PARK, S. pyogenes, and H. influenzae (MICs = 16, 32, and 64 μg/ml, respectively, in a broth dilutiion assay
Reference: 23477-2,5
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A bacterial metabolite with anticancer properties; inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 µM; has antibacterial activity against Gram-positive...
Reference: 23491-2,5
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A phenalenone that inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM); less cytotoxic to HPB-M(a) cells (IC50 =...
Reference: 23766-2,5
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A cysteine protease inhibitor (Kis = 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively); inhibits the growth of T. brucei in vitro (IC50 = 30.87 μM); cytotoxic to...
Reference: 23824-2,5
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The minor component (
Reference: 23861-2,5
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A macrocyclic lactone antibiotic; active against Gram-positive bacteria and C. trachomatis
Reference: 23882-2,5
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A depsipeptide with no antibacterial or antifungal activity
Reference: 23896-2,5
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A C5a receptor antagonist (IC50 = 1.7 µg/L); an antibiotic active against Gram-positive bacteria; decreases MDP-induced inflammation in mice when administered at a dose of 0.5 mg/kg and concanavalin A-induced...
Reference: 23914-2,5
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A cyclic tripeptide with insecticidal activity; toxic to fall web worms (LD50 = 100 µg/g) and to silkworms; has no antifungal activity against C. albicans and does not have antimicrobial activity up to a concentration...
Reference: 24179-2,5
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A Streptomyces metabolite; structurally similar to lydicamycin; active against Gram-positive bacteria (MICs = 0.39-3.13 µg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 µg/ml); ineffective against...
Reference: 24208-2,5
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A lichen metabolite with diverse biological activities; cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively); inhibits growth of M. tuberculosis (MIC = 41.7 μM); reduces...
Reference: 24917-2,5
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A fungal metabolite; produced by A. glaucus (A. clavatus), A. alliaceus, and A. niger; toxic to day-old chicks (LD100 = 62.5 mg/kg)
Reference: 24920-2,5
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A fungal metabolite; the hydroquinone form of aurantiogliocladin
Reference: 24924-2,5
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An inhibitor of PLA2 ( IC50 = 39 μM); inhibits release of arachidonic acid from rat polymorphonuclear leukocytes (IC50 = 24 μM); inhibits radioligand binding to L-type calcium channels in porcine heart membranes (IC50...
Reference: 25017-2,5
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A depsidone that preferentially inhibits growth of HT-29 human colon adenocarcinoma cells over non-malignant cells (IC50s = 29.29 and 2,478.4 µg/ml, respectively)
Reference: 25082-2,5
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A fungal metabolite; dietary administration reduces C. hemipterus larvae feeding by 21% at 100 ppm
Reference: 25087-2,5
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A fungal metabolite; inhibits the growth of HL-60 cells (IC50 = 20 µM)
Reference: 25089-2,5
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A fungal metabolite; cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml); has activity against T. foetus in vitro (IC50 = 100 μg/ml)
Reference: 25115-2,5
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A cyclic heptapeptide containing GABA
Reference: 25121-2,5
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A fungal metabolite; inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, at 100 ppm; inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone...
Reference: 25205-2,5
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A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer...
Reference: 25207-2,5
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A fungal metabolite; NK1 antagonist (Ki = 170 μM)
Reference: 25208-2,5
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A fungal metabolite; inhibits HIV-1 integrase (IC50s = 350 and 268 µM for 3’-processing and strand transfer activity, respectively); has been used as a standard for dereplication of natural products
Reference: 25479-2,5
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A macrolide bacterial metabolite; toxic to L. separata fourth instar larvae at 20 ppm; toxic to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 µg/ml)
Reference: 25484-2,5
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A fungal metabolite; reduces Aβ aggregate-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM); induces tremors in mice at 30 mg/kg
Reference: 25485-2,5
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A bacterial metabolite; cytotoxic to HeLa and Ehrlich cells (IC50s = 7.3 and 1.2 μg/ml, respectively)
Reference: 25513-2,5
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A cyclic thiopeptide fungal metabolite
Reference: 25515-2,5
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A nitro-containing bacterial metabolite; has mosquitocidal activity against A. aegypti at 6.25 mg/L; has nematocidal activity against C. elegans
Reference: 25516-2,5
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A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3...
Reference: 25521-2,5
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An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a...
Reference: 25531-2,5
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A cyclodepsipeptide fungal metabolite
Reference: 25761-2,5
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An antibiotic; inhibits the growth of Gram-positive bacteria, including MRSA, B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml)
Reference: 25762-2,5
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An antibiotic; active against S. aureus bacteria at 32 µg/ml; inhibits growth of KB cells (IC50 = 0.52 µg/ml); intercalates into bacteriophage PM2 DNA; toxic to rats (LD50 = 450 mg/kg, i.v.)
Reference: 26242-2,5
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A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma...
Reference: 26462-2,5
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A fungal metabolite; inactive against P. falciparum, C. albicans, and M. tuberculosis; not cytotoxic to KB or BC-1 cells
Reference: 26523-2,5
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A fungal metabolite; phytotoxic against a variety of plants
Reference: 26599-2,5
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A metabolite of febuxostat; is formed via glucuronidation of febuxostat by UGTs
Reference: 26680-2,5
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A fungal metabolite with anthelmintic and insecticidal activities; lethal to C. elegans (LD50 = 6 μg/ml); lethal to O. fasciatus (LD50 = 0.089 μg/nymph); oral administration reduces T. colubriformis fecal egg count in...
Reference: 26681-2,5
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An antibiotic originally isolated from Bacillus; has activity against Gram-positive, but not Gram-negative, bacteria; inhibits the growth of B. subtilis, B. anthracis, S. aureus, S. pyogenes, and S. pneumoniae strains...

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