Category: Reagents

Reference: AG-CN2-0059
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Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor...
Reference: AG-CN2-0063
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Potent anticancer compound. Anti-angiogenic. VEGF, VE-cadherin phosphorylation, matrix metalloproteinase and urokinase-plasminogen activator (uPA) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. Modulates chronic...
Reference: AG-CN2-0064
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Anti-inflammatory. Increases nitric oxide (NO) production [1]. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II) [2, 5]. Antioxidant [3]. Anti-viral. Shows anti-hepatitis B...
Reference: AG-CN2-0065
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Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively...
Reference: AG-CN2-0066
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Aminoglycoside antibiotic. Protein synthesis inhibitor. Causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site....
Reference: AG-CN2-0067
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Insecticidal and cytotoxic [1]. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines [2, 3, 4, 9]....
Reference: AG-CN2-0068
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Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1]. Cytotoxic and insecticidal [2]. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6]. Does not inhibit...
Reference: AG-CN2-0069
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Lipodepsipeptide (LDP) [1]. Used as a diagnostic tool to identify tolaasin-producing bacteria pathogenic to mushrooms and responsible for brown blotch disease [1, 5]. Has haemolytic activity. Permeabilizes lipid...
Reference: AG-CN2-0070
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Potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to ponasterone A (Prod. No. AG-CN2-0053 http://www.adipogen.com/ag-cn2-0053/ponasterone-a.html )....
Reference: AG-CN2-0071
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Steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva...
Reference: AG-CN2-0072
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A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of...
Reference: AG-CN2-0073
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A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in...
Reference: AG-CN2-0074
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Antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor. Axonal cytoskeleton modulator. Inhibitor of autophagosome-lysosome fusion. Apoptosis inducer. Thiocolchicine-dimers were shown to be...
Reference: AG-CN2-0075
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Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic,...
Reference: AG-CN2-0076
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Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties....
Reference: AG-CN2-0077
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Noncaloric natural sweetener, 300 times more potent than sucrose [1]. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression....
Reference: AG-CN2-0078
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Aminonucleoside antibiotic. Protein synthesis inhibitor. Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation. Translational inhibitor in...
Reference: AG-CN2-0079
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Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase...
Reference: AG-CN2-0080
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Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and...
Reference: AG-CN2-0082
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Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6]. Might be a reasonable PKC-independent TRPV4 channels agonist [5].
Reference: AG-CN2-0083
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Antifungal and antifertility compound [1, 3]. Antitumor compound [2, 7-9, 13]. PPARalpha signaling agonist [4]. Angiogenesis inhibitor [5, 6, 11]. Apoptosis and autophagy inducer [7, 9, 15, 17]....
Reference: AG-CN2-0084
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Anticancer compound [1, 2, 10, 14]. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle [1, 2, 14]. HIV-1 replication inhibitor [3]. Anti-inflammatory [4, 9, 11]. Vasodilatation inducer...
Reference: AG-CN2-0085
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Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which...
Reference: AG-CN2-0086
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Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K [1-3, 9, 14, 15]. Inhibits the tyrosine phosphorylation of STAT3 and STAT5 [4]. Potent...
Reference: AG-CN2-0087
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Antiprotozoal [1]. Potent inhibitor of histone deacetylase (HDAC) [1,2]. Inhibits proliferation [2,3]. Induces cell cycle arrest at the G1 phase [2]. Induces hyperacetylation of histone H4 [5]. Apoptosis inducer...
Reference: AG-CN2-0088
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Antibiotic [1]. Caffeine-like Ca2+ releaser in heavy sarcoplasmic reticulum (HSR) [2]. Antifungal [3]. Chitinase inhibitor [3]. DNA methyltransferase inhibitor [4]. Histone deacetylase (HDAC) inhibitor [4, 5]....
Reference: AG-CN2-0089
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Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6]. Widely used tool to investigate cAMP as a second messenger [15]. Inotropic and antihypertensive. Smooth muscle...
Reference: AG-CN2-0090
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Shows calcium-antagonistic and vasorelaxant activity [1,3]. Antibacterial [2]. Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor [4,5,9]. Hepatoprotective [5, 6]. Anticancer compound....
Reference: AG-CN2-0091
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Antibiotic [1]. DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4]. Topoisomerase I and II inhibitor (weaker than DNA helicase) [2]. DNA...
Reference: AG-CN2-0092
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Mycotoxin [1]. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP [2]. Antitumor agent. Antimetastatic [2].
Reference: AG-CN2-0093
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Potent and selective protein phosphatase 2A (PP2A) inhibitor [4-7]. Cell adhesion inhibitor [1]. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to...
Reference: AG-CN2-0097
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Indolocarbazole alkaloid antibiotic. [1]. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5]. Anticancer compound....
Reference: AG-CN2-0098
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Anticancer and antimetastatic agent that induces apoptosis and modulates autophagy. Shown to inhibits kinase signalling, including PKC(epsilon) and Src kinase, HDAC, Phosphatidylinositol 3-kinase (PI3K) / Akt and p90...
Reference: AG-CN2-0100
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Antibiotic [1-3]. Antifungal [1-3]. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor [4, 5, 7]. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator [6, 8]....
Reference: AG-CN2-0101
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Antibiotic [1, 2]. Antiprotozoal. Antimicrobial [3, 6]. Cytotoxic and genotoxic in various mammalian cells [4]. Mitochondrial permeability transition pore (MPTP) activator [5-7]. Apoptosis inducer [7-9, 14]. ERK and...
Reference: AG-CN2-0102
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Shows strong gastrointestinal motor stimulating (GMS) activity [1, 2, 5]. Motilin receptor agonist [3, 6]. Stimulates smooth muscle cell contraction [3]. Stimulates cholinergic neurons in a non-vagal pathway [4]....
Reference: AG-CN2-0103
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beta-Lactone antibiotic [1]. Antibacterial and antifungal [1, 4]. Specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active...
Reference: AG-CN2-0104
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Induces neuritogenesis [1, 3]. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex) [2, 4, 7]. Blocks proteasome activity by targeting the...
Reference: AG-CN2-0105
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Red-pigmented antibiotic [1]. Antimalarial [2, 13]. Immunosuppressive [3, 7, 11, 12]. Apoptosis inducer [4-6, 15]. Cytotoxic. Induces phosphorylation of p38-MAPK [8]. Antimetastatic. Tumor invasion inhibitor [9]....
Reference: AG-CN2-0106
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Antibiotic [1]. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2) [1-6, 8, 9]. Anti-angiogenic [10]. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and...
Reference: AG-CN2-0107
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Peptide antibiotic [1]. Induces root curvature and malformation in plants [1]. Antibacterial [1, 2], antimalarial and antitrypanosomal [4]. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to...
Reference: AG-CN2-0109
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Diacylglycerol acyltransferase (DGAT) inhibitor [1-4]. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes...
Reference: AG-CN2-0110
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Diacylglycerol acyltransferase (DGAT) inhibitor [1-4]. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes...
Reference: AG-CN2-0111
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Phytotoxin [1, 4]. Potent and specific PKC inhibitor. Competes for the phorbol binding site [2, 3, 6]. Anticancer compound. Cytotoxic [5, 6, 7]. Antiproliferative [5, 6]. Antiparasitic [7, 8]. Antimicrobial [8]....
Reference: AG-CN2-0112
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Hydroxy-acid of antibiotic 1233A. Antibiotic. Antibacterial. Shows low toxicity on zebrafish embryos (48h, 10 µM).
Reference: AG-CN2-0113
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Antibiotic. Hypotensive vasodilator. Calcium channel antagonist. Potent and selective CB1 receptor antagonist.
Reference: AG-CN2-0114
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Antibiotic [1, 2]. Antibacterial [1-6]. Antifungal [1-6]. Anticancer compound [3, 4]. Inhibits anti-apoptotic functions regulated by Bcl-2 [7]. Circumvents arbekacin (ABK)-resistance in MRSA by inhibiting the...
Reference: AG-CN2-0115
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Phytotoxin [1-3, 5]. Derivative of HDAC inhibitor chlamydocin [1-3, 5] Similar chemical structure to the TAN-1746 compounds (potent HDAC inhibitors) [4].
Reference: AG-CN2-0116
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Potent antibiotic. Bacteriocin. Antibacterial. Broad spectrum activity against Gram-positive and Gram-negative bacteria. Herbicidal. Enterocin is a small molecular weight secondary metabolite and should not be...
Reference: AG-CN2-0117
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Antifungal [1]. Anticancer compound. Cytotoxic to human cancer cell lines [2, 3].
Reference: AG-CN2-0118
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Antibiotic [1, 2]. Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH [3-7, 10, 11]. Anticancer compound [8]. Selectively...
Reference: AG-CN2-0119
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Antifungal [1, 2]. Antibacterial against Gram-positive bacteria [1, 2].
Reference: AG-CN2-0120
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Peptide with lasso structure. Antimycobacterial.
Reference: AG-CN2-0121
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Antibacterial. Selectively inhibits a Hof1 deletion strain.
Reference: AG-CN2-0122
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Plant growth inhibitor [1]. Mycotoxin. Acyl-CoA-cholesterol acyltransferase (ACAT) inhibitor [3, 6]. Anticancer compound. Cytotoxic [4]. Non-peptidic oxytocin receptor antagonist [5]. Calpain inhibitor [7].
Reference: AG-CN2-0123
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Antibiotic [1, 2]. Free radical scavenger [1]. Lipid peroxidation inhibitor [1]. Antimicrobial activity against Candida albicans [1]. Gelatinase A (MMP-2) inhibitor [3]. Anticancer. Cytotoxic [3]. DNA synthesis...
Reference: AG-CN2-0124
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Antibiotic [1]. Antibacteriophage. Antiviral [2]. Mycotoxin [3]. DNA replication, transcription and repair inhibitor [4]. Antibacterial [5]. RNA polymerase and ribonuclease H inhibitor [6]. Insecticidal. Cytotoxic...
Reference: AG-CN2-0125
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Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor [1-3, 6]. Tremorgenic [4, 5]. Cholesteryl ester (CE) synthesis inhibitor [6, 7].
Reference: AG-CN2-0126
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Steroidal antibiotic. Belongs to the Viridin family, including Wortmannin (Prod. No. AG-CN2-0023 http://www.adipogen.com/ag-cn2-0023/wortmannin.html ). Antifungal. Phytotoxin. Shows necrotic activity on plants....
Reference: AG-CN2-0127
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Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 2]. Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) inhibitor [3-7]. Specific M phase inhibitor [4].
Reference: AG-CN2-0128
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Cyclic peptide antibiotic Antibacterial.
Reference: AG-CN2-0129
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Antibiotic. Antibacterial Antifungal. Inhibits the biosynthesis of cyclic peptide quormones in Gram-positive bacteria. Lead compound for antipathogenic drugs that target the quorum-sensing-mediated virulence...
Reference: AG-CN2-0130
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Antibiotic [1]. Antiprotozoal [1]. Antifungal [2]. Anticancer [3-7]. ATP synthesis inhibitior [3, 4]. Haemolytic agent [5]. Antioomycete [8]. Spermidine-induced autoactivation inhibitor [9]. Plasma hyaluronan-binding...
Reference: AG-CN2-0131
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Specific anti-mycobacterial. Inhibits growth of Mycobacteria smegmatis but also Mycobacteria tuberculosis. M. smegmatis is used as a model for mycobacterial species. It is useful for the research analysis of other...
Reference: AG-CN2-0132
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Antibiotic [1]. Pollen growth and development inhibitor [2-4].
Reference: AG-CN2-0133
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Antibiotic [2,3] Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu) [4-7]. Type 3 secretion system (T3SS) inhibitor [8]. Growth promotor in poultry [1].
Reference: AG-CN2-0134
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Antimicrobial [1,2]. Phytotoxic [3]. Specific acetylcholinesterase (AChE) inhibitor [4].
Reference: AG-CN2-0135
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Free radical scavenger and antioxidant [1]. Potential compound to neutralize radioactive and toxic wastes and "heal" soils. Chelates and binds scores of minerals into a bioavailable form used by cells [1]. Shown to...
Reference: AG-CN2-0136
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Antimicrobial [1]. Phytotoxic [1,2].
Reference: AG-CN2-0137
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Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor [1]. HIV-1 integrase inhibitor [2].
Reference: AG-CN2-0138
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Mycotoxin. Antibacterial agent. ADP transport inhibitor. NADH dehydrogenase (NADH-Coenzyme Q oxidoreductase; Complex I) inhibitor. Inhibits mitochondrial respiration and oxidative phosphorylation (OXPHOS). Human CCR5...
Reference: AG-CN2-0139
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Plasminogen activator inhibitor (PAI-1) [1]. Glucose uptake stimulator [2].
Reference: AG-CN2-0140
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Antiprotozoal (Leishmania) [1]. Antifungal [2].
Reference: AG-CN2-0141
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Antibiotic [1]. TNF-alpha-induced NF-kappaB activation inhibitor [1]. Antiangiogenic [1]. Apoptosis inducer [2-4]. Anticancer compound. Selective cytotoxic against several cancer cell lines [2-4]. Tyrosinase inhibitor...
Reference: AG-CN2-0142
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Tremorgenic mycotoxin [1, 2]. Potent and specific, irreversible acetylcholinesterase (AChE) inhibitor [3-7].
Reference: AG-CN2-0143
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Antibiotic [7]. Antifungal penicillide [8]. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor [2]. Strong pp60c-Src inhibitor [3]. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor...
Reference: AG-CN2-0144
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Mycotoxin [1, 5, 7, 8]. Protein farnesyltransferase (PFTase) inhibitor [1-3]. Anti-cancer compound [1-3]. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells [4, 6].
Reference: AG-CN2-0145
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Antibiotic [1]. Anthelmintic agent [1]. Paralytic against Bombyx mori [2, 3].
Reference: AG-CN2-0146
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Antibiotic [1]. Lariat peptide antiviral [1]. Anti-HIV and anti-HSV (Herpes simplex virus) agent [4-6]. Fsr quorum sensing inhibitor [7-9]. Calmodulin-activated myosin light chain kinase (MLCK) inhibitor [2, 3].
Reference: AG-CN2-0147
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Antibiotic [1]. Antiprotozoal [1]. Antifungal and phytotoxic compound [1, 6]. Anti-inflammatory [7]. TGF-beta signaling inhibitor [8] Anticancer compound [2, 9]. Inhibits expression of inducible nitric oxide synthase...
Reference: AG-CN2-0148
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Antibiotic [1, 2]. Antimalaria agent [2].
Reference: AG-CN2-0149
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Antibiotic [1]. Antifungal and antibacterial compound [1, 2, 6]. Specific mitochondrial complex II (succinate ubiquinone oxidoreductase; succinate dehydrogenase) inhibitor [3, 5]. Herbicidal activity [4]. Anthelmintic...
Reference: AG-CN2-0150
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Antibiotic [1, 6]. Anti-mycobacterial [7]. Siderophore (iron (Fe) chelating compound) [5, 8]. Inducer of morphological changes in insect cells [3]. Antioxidant [4]. Anticancer compound [2, 8].
Reference: AG-CN2-0152
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Antibiotic [1, 2]. Cell-cell adhesion inhibitor [1, 2]. Antimetastatic compound [1, 2, 5]. Antifungal [3]. Antimicrobial [4].
Reference: AG-CN2-0154
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Antimitotic. Cell cycle inhibitor at the G2/M phase [3, 4]. Antiproliferative [3]. Weak CNS stimulant with weak inhibitory activity on blood platelet aggregation [1, 2]. Mycotoxin [1].
Reference: AG-CN2-0155
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Antibiotic. Mycotoxin. Very weak cytotoxic activity. Antifungal. Inhibits cell wall biosynthesis. Nerve growth factor (NGF) potentiator.
Reference: AG-CN2-0156
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Antioxidant. Radical scavenging activity towards DPPH and superoxide [3]. Shows a suppressive effect on the expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs)...
Reference: AG-CN2-0157
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Antibiotic [1, 3, 4]. Anti-viral compound [1]. Antifungal (weak) [2]. Anti-protozoal (Trypanosoma, Trichomonas) [2, 5].
Reference: AG-CN2-0158
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Antibiotic [1-3]. Antimycoplasma [1, 3, 4]. Antifungal compound [1, 3]. Anti-malarial agent [5]. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6]. Potential anticancer compound. Inducer...
Reference: AG-CN2-0159
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Antibiotic [1-3]. Active against Gram-positive bacteria [1, 2]. Active against Spodoptera eridania [1, 2].
Reference: AG-CN2-0160
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Antibiotic [1]. Stereoisomer of chrodrimanin B, which is an insecticidal compound [2].
Reference: AG-CN2-0161
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Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not...
Reference: AG-CN2-0162
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Antibiotic [1]. Inducer of morphological deformation of the conidia of Pyricularia oryzae [1].
Reference: AG-CN2-0163
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Derivative of aszonalenin, a substance P inhibitor.
Reference: AG-CN2-0164
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Antibiotic [1-3]. Acetylcholinesterase (AChE) inhibitor [3]. Anti-inflammatory compound [1, 4]. Tumor necrosis factor (TNF) inhibitor [1, 4].
Reference: AG-CN2-0165
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Antibiotic [1, 2, 6]. Antifungal [6]. Nematicidal [4]. Phytotoxic [3]. TGF-beta signaling inhibitor [9] Anticancer compound [5, 6, 8, 10]. Strong activator of the heat shock response [8]. Inhibitor of the appressorium...
Reference: AG-CN2-0166
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Boron-containing macrolide antibiotic [1]. Antibacterial [1]. Antiprotozoal (Plasmodium, Babesia) [2]. Anti-HIV compound [3,6]. Ca2+ homeostasis modulator [4]. Potentiator of bleomycin-induced anti-tumor activity [5]....
Reference: AG-CN2-0167
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Tremorgenic [1]. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels [2]. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)) [3]....
Reference: AG-CN2-0168
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Cytotoxic. Melanogenesis inhibitor without cytotoxicity.

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