Paxilline

Tremorgenic [1]. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels [2]. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)) [3]. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor [4]. Liver X receptor (LXRalpha and LXRbeta; NR1H3 and NR1H2) agonist in biochemical and in vitro cell-based assays [5]. Anticonvulsant [6]. Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis [7]. Shown to protect neuronal cells against glutamate-induced cell death [8].