Reagents (2)

Garcinol

Reference: SM52-25

€0.00 (tax incl.)

Garcinol predominantly down-regulates global gene expression in HeLa cells. Additional research shows that Garcinol exhibits anti-carcinogenic and anti-inflammatory properties through selectively suppressing...

GDC-0449

Reference: SM54-5

€0.00 (tax incl.)

GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding...

GDC-0449

Reference: SM54-25

€0.00 (tax incl.)

GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding...

GDC-0449

Reference: SM54-50

€0.00 (tax incl.)

GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding...

GDC-0449

Reference: SM54-200

€0.00 (tax incl.)

GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding...

GDC-0941

Reference: SM19-2

€0.00 (tax incl.)

GDC-0941 plays a vital role in diverse cellular functions such as cell growth and proliferation. This small molecule is deregulated in a number of conditions, including cancer.

GDC-0941

Reference: SM19-10

€0.00 (tax incl.)

GDC-0941 plays a vital role in diverse cellular functions such as cell growth and proliferation. This small molecule is deregulated in a number of conditions, including cancer.

GDC-0941

Reference: SM19-25

€0.00 (tax incl.)

GDC-0941 plays a vital role in diverse cellular functions such as cell growth and proliferation. This small molecule is deregulated in a number of conditions, including cancer.

GDC-0941

Reference: SM19-50

€0.00 (tax incl.)

GDC-0941 plays a vital role in diverse cellular functions such as cell growth and proliferation. This small molecule is deregulated in a number of conditions, including cancer.

GDC-0941

Reference: SM19-200

€0.00 (tax incl.)

GDC-0941 plays a vital role in diverse cellular functions such as cell growth and proliferation. This small molecule is deregulated in a number of conditions, including cancer.

Geldanamycin

Reference: SM55-2

€0.00 (tax incl.)

Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin...

Geldanamycin

Reference: SM55-10

€0.00 (tax incl.)

Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin...

Geldanamycin

Reference: SM55-25

€0.00 (tax incl.)

Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin...

Geldanamycin

Reference: SM55-50

€0.00 (tax incl.)

Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin...

Geldanamycin

Reference: SM55-250

€0.00 (tax incl.)

Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin...

Go 6983

Reference: SM20-1

€0.00 (tax incl.)

Go 6983 inhibits intracellular Ca2+ accumulation, suggesting a mechanism for its vasodilator properties. The inhibition of PKC signaling is an efficient strategy to establish and maintain pluripotent rat embryonic...

Go 6983

Reference: SM20-5

€0.00 (tax incl.)

Go 6983 inhibits intracellular Ca2+ accumulation, suggesting a mechanism for its vasodilator properties. The inhibition of PKC signaling is an efficient strategy to establish and maintain pluripotent rat embryonic...

Go 6983

Reference: SM20-10

€0.00 (tax incl.)

Go 6983 inhibits intracellular Ca2+ accumulation, suggesting a mechanism for its vasodilator properties. The inhibition of PKC signaling is an efficient strategy to establish and maintain pluripotent rat embryonic...

GSK429286A

Reference: SM21-2

€0.00 (tax incl.)

GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

GSK429286A

Reference: SM21-10

€0.00 (tax incl.)

GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

GSK429286A

Reference: SM21-50

€0.00 (tax incl.)

GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

GX15-070

Reference: SM56-2

€0.00 (tax incl.)

GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1...

GX15-070

Reference: SM56-10

€0.00 (tax incl.)

GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1...

GX15-070

Reference: SM56-50

€0.00 (tax incl.)

GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1...

GX15-070

Reference: SM56-200

€0.00 (tax incl.)

GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1...

ID-8

Reference: SM01-1

€0.00 (tax incl.)

ID-8 enables the long term expansion of embryonic stem cells (ESC). ESC treated with ID-8 in a serum-free medium were subsequently consistently differentiated into many cell types, including neurons, muscle cells and...

ID-8

Reference: SM01-5

€0.00 (tax incl.)

ID-8 enables the long term expansion of embryonic stem cells (ESC). ESC treated with ID-8 in a serum-free medium were subsequently consistently differentiated into many cell types, including neurons, muscle cells and...

ID-8

Reference: SM01-50

€0.00 (tax incl.)

ID-8 enables the long term expansion of embryonic stem cells (ESC). ESC treated with ID-8 in a serum-free medium were subsequently consistently differentiated into many cell types, including neurons, muscle cells and...

ID-8

Reference: SM01-100

€0.00 (tax incl.)

ID-8 enables the long term expansion of embryonic stem cells (ESC). ESC treated with ID-8 in a serum-free medium were subsequently consistently differentiated into many cell types, including neurons, muscle cells and...

IM-12

Reference: SM04-2

€0.00 (tax incl.)

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small...

IM-12

Reference: SM04-10

€0.00 (tax incl.)

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small...

IM-12

Reference: SM04-25

€0.00 (tax incl.)

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small...

IM-12

Reference: SM04-100

€0.00 (tax incl.)

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small...

IM-12

Reference: SM04-500

€0.00 (tax incl.)

IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small...

Irinotecan Hydrochloride Trihydrate

Reference: SM61-5

€0.00 (tax incl.)

As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the...

Irinotecan Hydrochloride Trihydrate

Reference: SM61-25

€0.00 (tax incl.)

As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the...

Irinotecan Hydrochloride Trihydrate

Reference: SM61-100

€0.00 (tax incl.)

As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the...

Irinotecan Hydrochloride Trihydrate

Reference: SM61-250

€0.00 (tax incl.)

As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the...

Irinotecan Hydrochloride Trihydrate

Reference: SM61-1000

€0.00 (tax incl.)

As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the...

IWP-2

Reference: SM39-2

€0.00 (tax incl.)

IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem...

IWP-2

Reference: SM39-10

€0.00 (tax incl.)

IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem...

IWP-2

Reference: SM39-50

€0.00 (tax incl.)

IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem...

IWP-2

Reference: SM39-100

€0.00 (tax incl.)

IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem...

JNJ-10198409

Reference: SM62-1

€0.00 (tax incl.)

JNJ-10198409 displays potent antiproliferative properties in human tumor cell lines and antiangiogenic activity.

JNJ-10198409

Reference: SM62-5

€0.00 (tax incl.)

JNJ-10198409 displays potent antiproliferative properties in human tumor cell lines and antiangiogenic activity.

JNJ-10198409

Reference: SM62-50

€0.00 (tax incl.)

JNJ-10198409 displays potent antiproliferative properties in human tumor cell lines and antiangiogenic activity.

KY02111

Reference: SM64-2

€0.00 (tax incl.)

KY02111 promotes differentiation of human pluripotent stem cells (hPSC) to cardiomyocytes by inhibiting Wnt signaling in hPSC in a manner that is distinct from that of previously studied Wnt inhibitors. The...

KY02111

Reference: SM64-10

€0.00 (tax incl.)

KY02111 promotes differentiation of human pluripotent stem cells (hPSC) to cardiomyocytes by inhibiting Wnt signaling in hPSC in a manner that is distinct from that of previously studied Wnt inhibitors. The...

KY02111

Reference: SM64-50

€0.00 (tax incl.)

KY02111 promotes differentiation of human pluripotent stem cells (hPSC) to cardiomyocytes by inhibiting Wnt signaling in hPSC in a manner that is distinct from that of previously studied Wnt inhibitors. The...

LDN193189

Reference: SM23-1

€0.00 (tax incl.)

LDN193189 inhibits ectopic ossification and it is a potential agent in the treatment of NSCLC lung tumors, showing significant in-vivo clinical utility. LDN193189 has been used to reduce ectopic ossification in a...

LDN193189

Reference: SM23-5

€0.00 (tax incl.)

LDN193189 inhibits ectopic ossification and it is a potential agent in the treatment of NSCLC lung tumors, showing significant in-vivo clinical utility. LDN193189 has been used to reduce ectopic ossification in a...

LDN193189

Reference: SM23-10

€0.00 (tax incl.)

LDN193189 inhibits ectopic ossification and it is a potential agent in the treatment of NSCLC lung tumors, showing significant in-vivo clinical utility. LDN193189 has been used to reduce ectopic ossification in a...

LDN193189

Reference: SM23-50

€0.00 (tax incl.)

LDN193189 inhibits ectopic ossification and it is a potential agent in the treatment of NSCLC lung tumors, showing significant in-vivo clinical utility. LDN193189 has been used to reduce ectopic ossification in a...

LY294002

Reference: SM24-10

€0.00 (tax incl.)

LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mouse embryonic stem cells, LY294002 prevents self-renewal by inhibiting LIF2.

LY294002

Reference: SM24-50

€0.00 (tax incl.)

LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mouse embryonic stem cells, LY294002 prevents self-renewal by inhibiting LIF2.

LY294002

Reference: SM24-100

€0.00 (tax incl.)

LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mouse embryonic stem cells, LY294002 prevents self-renewal by inhibiting LIF2.

LY294002

Reference: SM24-1000

€0.00 (tax incl.)

LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mouse embryonic stem cells, LY294002 prevents self-renewal by inhibiting LIF2.

LY411575

Reference: SM25-1

€0.00 (tax incl.)

Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also...

LY411575

Reference: SM25-5

€0.00 (tax incl.)

Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also...

LY411575

Reference: SM25-10

€0.00 (tax incl.)

Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also...

LY411575

Reference: SM25-50

€0.00 (tax incl.)

Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also...

LY411575

Reference: SM25-100

€0.00 (tax incl.)

Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also...

NVP-BEZ235

Reference: SM69-25

€0.00 (tax incl.)

NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.

NVP-BEZ235

Reference: SM69-100

€0.00 (tax incl.)

NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.

NVP-BEZ235

Reference: SM69-1000

€0.00 (tax incl.)

NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.

PD0325901

Reference: SM26-2

€0.00 (tax incl.)

PD0325901 has potential antineoplastic activity. This molecule inhibits the growth of melanoma cell lines in-vitro and in-vivo.

PD0325901

Reference: SM26-10

€0.00 (tax incl.)

PD0325901 has potential antineoplastic activity. This molecule inhibits the growth of melanoma cell lines in-vitro and in-vivo.

PD0325901

Reference: SM26-25

€0.00 (tax incl.)

PD0325901 has potential antineoplastic activity. This molecule inhibits the growth of melanoma cell lines in-vitro and in-vivo.

PD0325901

Reference: SM26-100

€0.00 (tax incl.)

PD0325901 has potential antineoplastic activity. This molecule inhibits the growth of melanoma cell lines in-vitro and in-vivo.

PD173074

Reference: SM27-2

€0.00 (tax incl.)

PD173074 inhibits proliferation and differentiation of oligodendrocyte progenitors. PD173074 also blocks tumor growth in H510 and H69 SCLC xenograft models.

PD173074

Reference: SM27-10

€0.00 (tax incl.)

PD173074 inhibits proliferation and differentiation of oligodendrocyte progenitors. PD173074 also blocks tumor growth in H510 and H69 SCLC xenograft models.

PD173074

Reference: SM27-25

€0.00 (tax incl.)

PD173074 inhibits proliferation and differentiation of oligodendrocyte progenitors. PD173074 also blocks tumor growth in H510 and H69 SCLC xenograft models.

PD173074

Reference: SM27-100

€0.00 (tax incl.)

PD173074 inhibits proliferation and differentiation of oligodendrocyte progenitors. PD173074 also blocks tumor growth in H510 and H69 SCLC xenograft models.

PD184352

Reference: SM73-2

€0.00 (tax incl.)

PD184352 has anti-cancer properties, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell (ESC) lines.

PD184352

Reference: SM73-10

€0.00 (tax incl.)

PD184352 has anti-cancer properties, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell (ESC) lines.

PD184352

Reference: SM73-25

€0.00 (tax incl.)

PD184352 has anti-cancer properties, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell (ESC) lines.

PD184352

Reference: SM73-100

€0.00 (tax incl.)

PD184352 has anti-cancer properties, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell (ESC) lines.

PD98059

Reference: SM28-2

€0.00 (tax incl.)

PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines...

PD98059

Reference: SM28-10

€0.00 (tax incl.)

PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines...

PD98059

Reference: SM28-25

€0.00 (tax incl.)

PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines...

PD98059

Reference: SM28-50

€0.00 (tax incl.)

PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines...

PI-103 Hydrochloride

Reference: SM74-2

€0.00 (tax incl.)

In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells.

PI-103 Hydrochloride

Reference: SM74-10

€0.00 (tax incl.)

In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells.

PI-103 Hydrochloride

Reference: SM74-25

€0.00 (tax incl.)

In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells.

PI-103 Hydrochloride

Reference: SM74-100

€0.00 (tax incl.)

In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells.

Pifithrin μ

Reference: SM29-2.5

€0.00 (tax incl.)

Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.

Pifithrin μ

Reference: SM29-10

€0.00 (tax incl.)

Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.

Pifithrin μ

Reference: SM29-50

€0.00 (tax incl.)

Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.

PIK-75 Hydrochloride

Reference: SM76-2

€0.00 (tax incl.)

This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival...

PIK-75 Hydrochloride

Reference: SM76-10

€0.00 (tax incl.)

This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival...

PIK-75 Hydrochloride

Reference: SM76-50

€0.00 (tax incl.)

This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival...

PIK-75 Hydrochloride

Reference: SM76-100

€0.00 (tax incl.)

This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival...