Quote Irinotecan Hydrochloride Trihydrate
As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan has a therapeutic effect in malignant brain tumors, with increased efficacy when combined in neural stem cells therapies.
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Reference:
SM61-1000
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