PD98059

PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines and causes G1 arrest by blocking p53-dependent p21 induction. This small molecule also enhances embryonic stem cell (ESC) self-renewal.

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