Quote Geldanamycin
Geldanamycin has antiproliferative and antitumor effects, as it binds to HSP90, inhibits the HSP90-mediated conformational maturation/refolding reaction. It interferes with cellular stress response. Geldanamycin decrease the expression of hypoxia inducible factor (HIF-1 alpha) in neural stem/progenitor cells.
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Reference:
SM55-50
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