VUF10460 Reference: 14665-10 A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120
VUF10460 Reference: 14665-25 A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120
VUF10460 Reference: 14665-5 A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120
BMS-536924 Reference: 14666-1 A dual inhibitor of IGF-1R kinase and IR (IC50s = 100 and 73 nM, respectively); blocks IFG-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF-1R