BMS-536924 Reference: 14666-10 A dual inhibitor of IGF-1R kinase and IR (IC50s = 100 and 73 nM, respectively); blocks IFG-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF-1R
BMS-536924 Reference: 14666-25 A dual inhibitor of IGF-1R kinase and IR (IC50s = 100 and 73 nM, respectively); blocks IFG-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF-1R
BMS-536924 Reference: 14666-5 A dual inhibitor of IGF-1R kinase and IR (IC50s = 100 and 73 nM, respectively); blocks IFG-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF-1R
9(Z),12(Z)-octadecadienoic-d11 acid, mg Reference: 71-1821 Synonyms: Linoleic Acid-d11, Telfairic Acid-d11
CYM 50308 Reference: 14667-1 A novel agonist of SIP4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM
9(Z),12(Z)-octadecadienoic-d11 acid, 1 mg Reference: 71-1821-1 Synonyms: Linoleic Acid-d11, Telfairic Acid-d11