VUF10460

A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120