NS 6180 Reference: 14664-25 An inhibitor of IKCa1/KCa3.1 channels (IC50 = 9.4 nM); inhibits A23187-induced hyperpolarization of human, mouse, and rat erythrocytes (IC50s = 14, 15, and 9 nM, respectively); selective over Nav and most Kv channels as well as 65 receptors and channels in a panel; inhibits T-lymphocyte activation and cytokine release in vitro (IC50 = ~50 nM); decreases colon inflammation and improves weight gain in a rat model of DNBS-induced IBD
NS 6180 Reference: 14664-5 An inhibitor of IKCa1/KCa3.1 channels (IC50 = 9.4 nM); inhibits A23187-induced hyperpolarization of human, mouse, and rat erythrocytes (IC50s = 14, 15, and 9 nM, respectively); selective over Nav and most Kv channels as well as 65 receptors and channels in a panel; inhibits T-lymphocyte activation and cytokine release in vitro (IC50 = ~50 nM); decreases colon inflammation and improves weight gain in a rat model of DNBS-induced IBD
NS 6180 Reference: 14664-50 An inhibitor of IKCa1/KCa3.1 channels (IC50 = 9.4 nM); inhibits A23187-induced hyperpolarization of human, mouse, and rat erythrocytes (IC50s = 14, 15, and 9 nM, respectively); selective over Nav and most Kv channels as well as 65 receptors and channels in a panel; inhibits T-lymphocyte activation and cytokine release in vitro (IC50 = ~50 nM); decreases colon inflammation and improves weight gain in a rat model of DNBS-induced IBD
VUF10460 Reference: 14665-1 A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120