NS 6180

An inhibitor of IKCa1/KCa3.1 channels (IC50 = 9.4 nM); inhibits A23187-induced hyperpolarization of human, mouse, and rat erythrocytes (IC50s = 14, 15, and 9 nM, respectively); selective over Nav and most Kv channels as well as 65 receptors and channels in a panel; inhibits T-lymphocyte activation and cytokine release in vitro (IC50 = ~50 nM); decreases colon inflammation and improves weight gain in a rat model of DNBS-induced IBD