HDAC4 (human, recombinant) Reference: 10009652-1 Source: 10 µg of recombinant N-terminal GST-tagged protein expressed in baculovirus expression system • MW: 75.2 kDa • HDAC4 is a Class IIa HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of nonhistone substrates.
NINJ1 blocking peptide Reference: GTX31596-PEP The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 878658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 29]
PTEN (human recombinant) Reference: 10009746-50 Source: Active human recombinant N-terminal His-tagged protein purified from Sf21 cells • Mr: 50.8 kDa • PTEN functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as Akt and PIP3. Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma, making PTEN an important tumor suppressor.
Neuroligin 2 blocking peptide Reference: GTX31597-PEP This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 28]
PtdIns-(4,5)-P2 Binding Protein Reference: 10009815-100 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) • PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
PtdIns-(4,5)-P2 Binding Protein Reference: 10009815-25 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) • PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
SKI2W blocking peptide Reference: GTX31599-PEP DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 28]
PtdIns-(4,5)-P2 Binding Protein Reference: 10009815-50 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) • PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
P2X7 blocking peptide Reference: GTX31600-PEP The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 21]
PtdIns-(3,4,5)-P3 Binding Protein Reference: 10009817-100 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~41.7 kDa (15.4 kDa native; 26.3 kDa GST-tagged) • PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3. PtdIns phosphates play a critical role in the generation and transmission of cellular signals. Due to PtdIns-(3,4,5)-P3 binding protein’s unique affinity for PtdIns-(3,4,5)-P3, this protein can be used to detect product formed by PI3-kinase in in vitro assays.
KCNK1 blocking peptide Reference: GTX31601-PEP This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 28]