PtdIns-(3,4,5)-P3 Binding Protein Reference: 10009817-25 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~41.7 kDa (15.4 kDa native; 26.3 kDa GST-tagged) • PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3. PtdIns phosphates play a critical role in the generation and transmission of cellular signals. Due to PtdIns-(3,4,5)-P3 binding protein’s unique affinity for PtdIns-(3,4,5)-P3, this protein can be used to detect product formed by PI3-kinase in in vitro assays.
SESN2 blocking peptide Reference: GTX31602-PEP This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 28]
PtdIns-(3,4,5)-P3 Binding Protein Reference: 10009817-50 Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~41.7 kDa (15.4 kDa native; 26.3 kDa GST-tagged) • PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3. PtdIns phosphates play a critical role in the generation and transmission of cellular signals. Due to PtdIns-(3,4,5)-P3 binding protein’s unique affinity for PtdIns-(3,4,5)-P3, this protein can be used to detect product formed by PI3-kinase in in vitro assays.
NF-κB (p50) (human, recombinant) Reference: 10009818-25 Source: Recombinant enzyme expressed in E. coli · MW: 74.5 kDa (p50-GST fusion) · As part of a dimer, this transcription factors binds with p65 to form NF-κB, which is responsible for regulating the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules
Wip1 blocking peptide Reference: GTX31604-PEP The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 28]
NF-κB (p65) (human, recombinant) Reference: 10009819-25 Source: Recombinant human N-terminal histidine-tagged p65 (386-480) expressed in E. coli • AA: 386-480 • MW: 12.1 kDA
HES5 blocking peptide Reference: GTX31605-PEP This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 28]
Fatty Acid Amide Hydrolase (human recombinant) Reference: 10010183-100 Source: recombinant human C-terminal His-tagged protein expressed in Sf21 cells · MW: 64.3 kDa
FABP5 (human, recombinant) Reference: 10010364-100 Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli · Mr: 18 kDa
Jagged 1 blocking peptide Reference: GTX31607-PEP The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 28]