Protein Tyrosine Phosphatase 1B (human recombinant) Reference: 10010896-100 Source: Active human recombinant protein purified from E. coli • Mr: 37.3 kDa • PTPs remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is of paramount importance to the regulation of the signaling events that underlie such fundamental processes as growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. One of the most heavily studied PTP proteins is PTP1B.
PJA1 blocking peptide Reference: GTX31608-PEP This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 21]
Hemopressin Reference: 10011038-1 A bioactive peptide fragment derived from hemoglobin a 1 chain; exhibits potent vasoactive biological activity, reducing rat blood pressure over a dosage range of 0.1-10 μg/kg; also a potent central cannabinoid (CB1) receptor antagonist conferring analgesia and pain relief or antinociception in vivo
MALT1 blocking peptide Reference: GTX31609-PEP This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 28]
TRIB3 blocking peptide Reference: GTX31610-PEP The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 28]
SIRT2 (human recombinant) Reference: 10011191-100 Source: Active recombinant N-terminal His-tagged enzyme amino acids 2-389 expressed in E. coli • Mr: 44.2 kDa • SIRT2 is a cytoplasmic protein responsible for the deacetylation of histone H4 and α-tubulin, a modification important for controlling the cell cycle. SIRT2 co-localizes with HDAC6 and microtubules and functions as a mitotic checkpoint in preventing chromosomal instability that can lead to hyperploid cells.
CRBN blocking peptide Reference: GTX31611-PEP This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 21]
SIRT3 (human, recombinant) Reference: 10011194-100 Source: Active recombinant N-terminal His-tagged enzyme amino acids 101-399 purified from E. coli · Mr: 37 kDa (theoretical); 33.5 kDa (observed) • SIRT3, is a mitochondrial protein that is synthesized as an enzymatically inactive protein. Human SIRT3 is activated by a matrix-processing peptidase. The constitutive expression of SIRT3 promotes the expression of PGC-1α, UCP1, and other genes involved in mitochondrial functions, indicating that SIRT3 modulates adaptive thermogenesis in BAT.
HELIOS blocking peptide Reference: GTX31612-PEP This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 28]
Protein Phosphatase 2A C subunit (human, recombinant, L309 deletion) Reference: 10011237-10 Source: Human recombinant PP2A catalytic subunit expressed in insect cells with an N-terminal octahistidine-tag followed by a streptactin-tag. The C-terminal leucine 309 was deleted. • MW: 38.6 kDa • PP2A is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth, and differentiation and is also thought to be a potential tumor suppressor.
SOX4 blocking peptide Reference: GTX31613-PEP This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 28]