15-Lipoxygenase-2 (human recombinant) Reference: 10011263-100 Source: Active human recombinant C-terminal His-tagged protein expressed in E. coli • MW: 76 kDa • Expression of 15-LO-2 appears to be restricted to prostate, lung, skin, and cornea and may play a role in the normal development of these tissues. The protein levels and enzymatic activity of 15-LO-2 are both down-regulated in prostate cancer compared with normal and benign prostate tissues, implicating a possible protective role for 15-LO-2 against tumor formation.
SLC29A4 blocking peptide Reference: GTX31614-PEP This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 28]
1-NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Reference: 10011300-1 Has the fluorophore NBD attached to the ω-end of the stearoyl chain of SAG; may be used to study interactions with proteins, utilization by cells and liposomes, and for the development of assays for lipid metabolism
1-NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Reference: 10011300-10 Has the fluorophore NBD attached to the ω-end of the stearoyl chain of SAG; may be used to study interactions with proteins, utilization by cells and liposomes, and for the development of assays for lipid metabolism
1-NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Reference: 10011300-5 Has the fluorophore NBD attached to the ω-end of the stearoyl chain of SAG; may be used to study interactions with proteins, utilization by cells and liposomes, and for the development of assays for lipid metabolism
SNRPN blocking peptide Reference: GTX31617-PEP The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or
1-NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Reference: 10011300-500 Has the fluorophore NBD attached to the ω-end of the stearoyl chain of SAG; may be used to study interactions with proteins, utilization by cells and liposomes, and for the development of assays for lipid metabolism
QSOX1 blocking peptide Reference: GTX31618-PEP This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
Soluble Epoxide Hydrolase (human recombinant) Reference: 10011669-50 Source: Active recombinant N-terminal His-tagged protein purified from Sf21 cells • MW: 64 kDa
ARID1A blocking peptide Reference: GTX31619-PEP This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isof