Soluble Epoxide Hydrolase (mouse recombinant) Reference: 10011670-50 Source: Active mouse recombinant N-terminal His-tagged protein purified from Sf21 cells • Mr: 64 kDa • sEH catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions.
MAGEA4 blocking peptide Reference: GTX31620-PEP This gene is a member of the MAGEA gene family. The members of this family encode proteins with 5 to 8% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 28]
Histone H2A (Xenopus, recombinant) Reference: 10261-1 Source: Recombinant protein expressed in E. coli • Mr: 13.9 kDa Histone 2A is one of the four histones that comprise a nucleosome protein core.
OATP2 blocking peptide Reference: GTX31621-PEP This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 29]
Histone H2B (Xenopus recombinant) Reference: 10262-1 Source: Recombinant protein expressed in E. coli • Mr: 13.7 kDa. Histone 2H2B is one of the core nucleosomal histones. It undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.
Histone H3 (human, recombinant) Reference: 10263-1 Source: Recombinant human histone H3 expressed in E. coli • Amino acids: 1-136 (full length) • MW: 15.5 kDa
PDI blocking peptide Reference: GTX31623-PEP This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 28]
Histone H4 (human, recombinant) Reference: 10264-1 Source: Recombinant protein expressed in E. coli • Mr: 11.5 kDa. Histone H4 is one of the core nucleosomal histones. It undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.
Golgin 97 blocking peptide Reference: GTX31624-PEP The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 21]
PAF Acetylhydrolase (human, recombinant) Reference: 10279-100 Source: recombinant N-terminal His-tagged protein purified from E. coli · Mr: 46.4 kDa
Hexokinase 1 blocking peptide Reference: GTX31625-PEP Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 29]