SIRT6 (human recombinant) Reference: 10315-100 Source: Active recombinant N-terminal His-tagged enzyme amino acids 1-355 expressed in E. coli • Mr: 43.7 kDa • SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature aging disorder associated with a shortened life span.
TRPC3 blocking peptide Reference: GTX31626-PEP The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 211]
SIRT7 (human, recombinant) Reference: 10316-100 Source: Recombinant human N-terminal hexahistidine-tagged enzyme expressed in E. coli • Mr: 49.3 kDa • SIRT7 activates transcription by RNA polymerase I and deacetylates p53. It prevents progressive deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
SIRT4 (human recombinant) Reference: 10317-100 Source: Recombinant N-terminal GST-tagged enzyme expressed in E. coli • MW: 61.9 kDa • SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase.
GAS6 blocking peptide Reference: GTX31628-PEP This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 214]
SIRT5 (human, recombinant) Reference: 10318-100 Source: Recombinant human N-terminal GST-tagged SIRT5 expressed in E. coli • Amino acids: 30-310 AA • MW: 60.6 kDa
ASK1 blocking peptide Reference: GTX31637-PEP Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 28]
SET8 (human recombinant) Reference: 10319-100 Source: Active recombinant N-terminal His-tagged protein amino acids 190-352, expressed in E. coli • MW: 21.1 kDa
Nephrin blocking peptide Reference: GTX31654-PEP This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 29]
SET7/9 (human recombinant) Reference: 10320-500 Source: Active recombinant N-terminal His-tagged SET7/9 purified from E. coli · Mr: 43.3 kDa • SET7/9 is exclusively a mono-methylase that methylates histone H3, tumor suppressor p53, and transcription factor TAF10. SET7/9 methylates p53 in response to DNA damage thereby activating p53 for subsequent acetylation.
NOD2 blocking peptide Reference: GTX31664-PEP This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq, Jul 28]