Cystathionine γ-Lyase (human, recombinant) Reference: 10329-100 Source: Recombinant protein expressed in E. coli • MW: 44.5 kDa
NOD2 blocking peptide Reference: GTX31665-PEP This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq, Jul 28]
JMJD2D (human, recombinant) Reference: 10335-100 Active recombinant N-terminal His-tagged protein expressed in E. coli • JMJD2D catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me2/3), leading to transcriptional repression and activation, respectively.
PAK6 blocking peptide Reference: GTX31672-PEP This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 213]
JMJD2A (human, recombinant) Reference: 10336-100 Source: Recombinant N-terminal His-tagged protein expressed in E. coli • Mr: 43 kDa • JMJD2A catalyzes the demethylation of trimethylated histone at lysine residues 9 and 36
PAK4 blocking peptide Reference: GTX31673-PEP PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 28]
12-Lipoxygenase (platelet-type, mouse recombinant) Reference: 10341-25 Source: Active recombinant N-terminal His-tagged protein expressed in insect cells • Mr: 76.4 kDa • Platelet-type 12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid.
TLR4 blocking peptide Reference: GTX31674-PEP The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 212]
Sphingosine Kinase 1 (human recombinant) Reference: 10348-25 Source: Human recombinant N-terminal His-tagged protein from Sf9 cells • SPHK1 catalyzes the production of sphingosine-1-phosphate, a lipid mediator with broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.
TLR4 blocking peptide Reference: GTX31675-PEP The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 212]
PRMT1 (human recombinant) Reference: 10350-100 Source: Active recombinant N-terminal GST-tagged protein expressed in E. coli • MW: 69.2 kDa • PRMT1 is a class I arginine methyltransferase that methylates arginine residues at a number of glycine and arginine rich regions (GAR motifs) in proteins including histone H4 at arginine 3.