Formaldehyde Dehydrogenase (P. putida recombinant) Reference: 10352-100 Source: Active recombinant N-terminal His-tagged protein expressed in E. coli • Mr: 44.6 kDa
BCL2L10 blocking peptide Reference: GTX31677-PEP The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 28]
G9a (human recombinant) Reference: 10353-50 Active recombinant N-terminal GST-tagged protein expressed in E. coli • G9a is a SET domain-containing methyltransferase that specficially mono- and di-methylates Histone H3 at lysine 9 (H3K9).
CARD10 blocking peptide Reference: GTX31678-PEP The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD1 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 16411) through BCL1 (MIM 63517) (Wang et al., 21 [PubMed 11259443]).[supplied by OMIM, Mar 28]
PAD4 (human, recombinant) Reference: 10500-1 Source: Active recombinant N-terminal His-tagged protein expressed in E. coli • MW: 75.8 kDa • PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.
ALS2CR2 blocking peptide Reference: GTX31679-PEP This gene encodes a protein that belongs to the serine/threonine protein kinase STE2 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 211]
PAD4 (human, recombinant) Reference: 10500-100 Source: Active recombinant N-terminal His-tagged protein expressed in E. coli • MW: 75.8 kDa • PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.
EED (human recombinant) Reference: 10628-50 Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells • Mr: 53.5 kDa • EED is a WD40 repeat-containing protein that forms part of the Polycomb repressive complex 2 (PRC2). The EED subunit does not contain methyltransferase activity. However, transcriptional repression by PRC2-mediated trimethylation of lysine 27 on Histone H3 (H3K27me3) has been shown to be dependent on EED binding to repressive histone marks.
MLL1 (human recombinant) Reference: 10658-1 Source: Recombinant protein expressed in E. coli • MW: 24.1 kDa