SIRT3 (human, recombinant)

Source: Active recombinant N-terminal His-tagged enzyme amino acids 101-399 purified from E. coli · Mr: 37 kDa (theoretical); 33.5 kDa (observed) • SIRT3, is a mitochondrial protein that is synthesized as an enzymatically inactive protein. Human SIRT3 is activated by a matrix-processing peptidase. The constitutive expression of SIRT3 promotes the expression of PGC-1α, UCP1, and other genes involved in mitochondrial functions, indicating that SIRT3 modulates adaptive thermogenesis in BAT.