PtdIns-(4,5)-P2 Binding Protein

Source: recombinant N-terminal GST-tagged protein purified from E. coli · Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) • PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.