C24 (2’(R)-hydroxy) Phytoceramide (t18:0/24:0) Reference: 28933-1 A naturally occurring sphingolipid; inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and iNOS levels; increases production of CXCL8, CXCL1, CCL2, and CCL20 in HUVECs in a concentration-dependent manner; a hydroxylated form of C24 phytoceramide
Reversin 121 Reference: 18603-1 A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM)
Reversin 121 Reference: 18603-5 A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM)
Reversin 121 Reference: 18603-500 A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM)
Akt Inhibitor XI Reference: 18604-1 A cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 µM); also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells