Pertactin from Bordetella pertussis (69 kDa protein) Reference: 28208-50 A virulence factor from B. pertussis; may have a role in Bordetella resistance to neutrophil-mediated clearance
KCNK12 blocking peptide Reference: GTX31840-PEP This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 28]
EI24 blocking peptide Reference: GTX31841-PEP This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 28]
Anthrax Edema Factor (EF) (recombinant from Bacillus anthracis) Reference: 28210-100 A component of EdTx produced by B. anthracis; comprised of an N-terminal PABD, an adenylyl cyclase domain, and a helical domain; binds oligomerized B. anthracis PA on the host cell surface; endocytosed by the host cell along with PA, together called EdTx, after which PA facilitates translocation of EF into the host cell cytoplasm; binds calmodulin at the helical domain, which activates its adenylyl cyclase activity, leading to an increase in intracellular cAMP
Adenylate Cyclase Toxin from Bordetella pertussis (recombinant, frozen liquid) Reference: 28211-50 A virulence factor in B. pertussis; has been used in the development of a microsphere-based multiplex antibody capture assay to quantify antibody amounts in acellular pertussis vaccines
Metalloendopeptidase OMA1 (human, recombinant) Reference: 28258-100 Source: Recombinant human N-terminal His-tagged OMA1 expressed in E. coli • Amino acids: 217-524 • MW: 37.1 kDa
LAP2 blocking peptide Reference: GTX31844-PEP The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 21]