GPX4 (human, recombinant) Reference: 26906-50 Source: Active recombinant N-terminal His-tagged protein expressed in E. coli strain C321.ΔA.exp • Amino acids: 1-170 (full length) • MW: 21.2 kDa
DYRK2 blocking peptide Reference: GTX31833-PEP DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 28]
GFAP (human, recombinant) Reference: 27353-100 Source: Recombinant N-terminal histidine-tagged GFAP expressed in E. coli • Amino acids: 2-432 • MW: 51.9 kDa
ATP2C1 blocking peptide Reference: GTX31834-PEP The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 211]
SETD3 (human, recombinant) Reference: 27355-100 Source: Recombinant N-terminal His-tagged SETD3 expressed in E. coli • Amino acids: 2-594 (full length) • MW: 69.2 kDa
Histone H3K27Me2 (23-34) (trifluoroacetate salt) Reference: 28142-1 A peptide fragment of histone H3; has been used in epitope mapping of the lupus-derived monoclonal antibody BT164
ROCK1 blocking peptide Reference: GTX31836-PEP This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 28]
Histone H3K36Me3 (26-46)-K-biotin (trifluoroacetate salt) Reference: 28144-250 A peptide fragment of histone H3; contains a serine-to-alanine substitution in the human histone H3 sequence; corresponds directly to the sequences for the yeast H3.1 sequence in S. octosporus and S. pombe and of the plant pathogenic fungus histone sequence in P. striiformis
ROCK2 blocking peptide Reference: GTX31837-PEP The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 28]
Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae (in low salt) Reference: 28206-500 A receptor-binding subunit of cholera toxin; binds to GM1 ganglioside receptors on the surface of mammalian cells and facilitates entry of the enzymatic subunit, cholera toxin subunit A; not toxic; has been used as a retrograde neuronal tracer in combination with anti-cholera toxin antibodies
Musashi 2 blocking peptide Reference: GTX31838-PEP This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 28]