Anthrax Edema Factor (EF) (recombinant from Bacillus anthracis)

A component of EdTx produced by B. anthracis; comprised of an N-terminal PABD, an adenylyl cyclase domain, and a helical domain; binds oligomerized B. anthracis PA on the host cell surface; endocytosed by the host cell along with PA, together called EdTx, after which PA facilitates translocation of EF into the host cell cytoplasm; binds calmodulin at the helical domain, which activates its adenylyl cyclase activity, leading to an increase in intracellular cAMP