LY379268 Reference: 15351-10 A group II mGluR inhibitor (EC50s = 2.69 and 4.48 nM, respectively for mGluR2 and mGluR3); over 80-fold selectivity over group I and III mGluRs; no agonist or antagonist activity against NMDA, AMPA, or kainate receptors up to a concentration of 100 µM; raises extracellular dopamine level in the prefrontal cortex to 168% basal level in treated rats (3 mg/kg)
Deltarasin hydrochloride Reference: B1261-50 inhibitor of KRAS-PDEδ interaction, potent and selective
LY379268 Reference: 15351-5 A group II mGluR inhibitor (EC50s = 2.69 and 4.48 nM, respectively for mGluR2 and mGluR3); over 80-fold selectivity over group I and III mGluRs; no agonist or antagonist activity against NMDA, AMPA, or kainate receptors up to a concentration of 100 µM; raises extracellular dopamine level in the prefrontal cortex to 168% basal level in treated rats (3 mg/kg)
YZ9 Reference: 15352-10 A potent inhibitor of the glycolysis enzyme PFKFB3, with an IC50 value of 183 nM in vitro; avidly competes with F6P at PFKFB3 (Ki = 94 nM); cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM
YZ9 Reference: 15352-100 A potent inhibitor of the glycolysis enzyme PFKFB3, with an IC50 value of 183 nM in vitro; avidly competes with F6P at PFKFB3 (Ki = 94 nM); cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM