Category: Reagents

Reference: AG-CN2-0091
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Antibiotic [1]. DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4]. Topoisomerase I and II inhibitor (weaker than DNA helicase) [2]. DNA...
Reference: AG-CN2-0092
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Mycotoxin [1]. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP [2]. Antitumor agent. Antimetastatic [2].
Reference: AG-CN2-0093
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Potent and selective protein phosphatase 2A (PP2A) inhibitor [4-7]. Cell adhesion inhibitor [1]. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to...
Reference: AG-CN2-0097
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Indolocarbazole alkaloid antibiotic. [1]. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5]. Anticancer compound....
Reference: AG-CN2-0098
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Anticancer and antimetastatic agent that induces apoptosis and modulates autophagy. Shown to inhibits kinase signalling, including PKC(epsilon) and Src kinase, HDAC, Phosphatidylinositol 3-kinase (PI3K) / Akt and p90...
Reference: AG-CN2-0100
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Antibiotic [1-3]. Antifungal [1-3]. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor [4, 5, 7]. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator [6, 8]....
Reference: AG-CN2-0101
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Antibiotic [1, 2]. Antiprotozoal. Antimicrobial [3, 6]. Cytotoxic and genotoxic in various mammalian cells [4]. Mitochondrial permeability transition pore (MPTP) activator [5-7]. Apoptosis inducer [7-9, 14]. ERK and...
Reference: AG-CN2-0102
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Shows strong gastrointestinal motor stimulating (GMS) activity [1, 2, 5]. Motilin receptor agonist [3, 6]. Stimulates smooth muscle cell contraction [3]. Stimulates cholinergic neurons in a non-vagal pathway [4]....
Reference: AG-CN2-0103
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beta-Lactone antibiotic [1]. Antibacterial and antifungal [1, 4]. Specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active...
Reference: AG-CN2-0104
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Induces neuritogenesis [1, 3]. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex) [2, 4, 7]. Blocks proteasome activity by targeting the...
Reference: AG-CN2-0105
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Red-pigmented antibiotic [1]. Antimalarial [2, 13]. Immunosuppressive [3, 7, 11, 12]. Apoptosis inducer [4-6, 15]. Cytotoxic. Induces phosphorylation of p38-MAPK [8]. Antimetastatic. Tumor invasion inhibitor [9]....
Reference: AG-CN2-0106
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Antibiotic [1]. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2) [1-6, 8, 9]. Anti-angiogenic [10]. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and...
Reference: AG-CN2-0107
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Peptide antibiotic [1]. Induces root curvature and malformation in plants [1]. Antibacterial [1, 2], antimalarial and antitrypanosomal [4]. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to...
Reference: AG-CN2-0109
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Diacylglycerol acyltransferase (DGAT) inhibitor [1-4]. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes...
Reference: AG-CN2-0110
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Diacylglycerol acyltransferase (DGAT) inhibitor [1-4]. Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes...
Reference: AG-CN2-0111
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Phytotoxin [1, 4]. Potent and specific PKC inhibitor. Competes for the phorbol binding site [2, 3, 6]. Anticancer compound. Cytotoxic [5, 6, 7]. Antiproliferative [5, 6]. Antiparasitic [7, 8]. Antimicrobial [8]....
Reference: AG-CN2-0112
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Hydroxy-acid of antibiotic 1233A. Antibiotic. Antibacterial. Shows low toxicity on zebrafish embryos (48h, 10 µM).
Reference: AG-CN2-0113
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Antibiotic. Hypotensive vasodilator. Calcium channel antagonist. Potent and selective CB1 receptor antagonist.
Reference: AG-CN2-0114
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Antibiotic [1, 2]. Antibacterial [1-6]. Antifungal [1-6]. Anticancer compound [3, 4]. Inhibits anti-apoptotic functions regulated by Bcl-2 [7]. Circumvents arbekacin (ABK)-resistance in MRSA by inhibiting the...
Reference: AG-CN2-0115
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Phytotoxin [1-3, 5]. Derivative of HDAC inhibitor chlamydocin [1-3, 5] Similar chemical structure to the TAN-1746 compounds (potent HDAC inhibitors) [4].
Reference: AG-CN2-0116
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Potent antibiotic. Bacteriocin. Antibacterial. Broad spectrum activity against Gram-positive and Gram-negative bacteria. Herbicidal. Enterocin is a small molecular weight secondary metabolite and should not be...
Reference: AG-CN2-0117
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Antifungal [1]. Anticancer compound. Cytotoxic to human cancer cell lines [2, 3].
Reference: AG-CN2-0118
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Antibiotic [1, 2]. Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH [3-7, 10, 11]. Anticancer compound [8]. Selectively...
Reference: AG-CN2-0119
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Antifungal [1, 2]. Antibacterial against Gram-positive bacteria [1, 2].
Reference: AG-CN2-0120
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Peptide with lasso structure. Antimycobacterial.
Reference: AG-CN2-0121
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Antibacterial. Selectively inhibits a Hof1 deletion strain.
Reference: AG-CN2-0122
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Plant growth inhibitor [1]. Mycotoxin. Acyl-CoA-cholesterol acyltransferase (ACAT) inhibitor [3, 6]. Anticancer compound. Cytotoxic [4]. Non-peptidic oxytocin receptor antagonist [5]. Calpain inhibitor [7].
Reference: AG-CN2-0123
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Antibiotic [1, 2]. Free radical scavenger [1]. Lipid peroxidation inhibitor [1]. Antimicrobial activity against Candida albicans [1]. Gelatinase A (MMP-2) inhibitor [3]. Anticancer. Cytotoxic [3]. DNA synthesis...
Reference: AG-CN2-0124
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Antibiotic [1]. Antibacteriophage. Antiviral [2]. Mycotoxin [3]. DNA replication, transcription and repair inhibitor [4]. Antibacterial [5]. RNA polymerase and ribonuclease H inhibitor [6]. Insecticidal. Cytotoxic...
Reference: AG-CN2-0125
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Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor [1-3, 6]. Tremorgenic [4, 5]. Cholesteryl ester (CE) synthesis inhibitor [6, 7].
Reference: AG-CN2-0126
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Steroidal antibiotic. Belongs to the Viridin family, including Wortmannin (Prod. No. AG-CN2-0023 http://www.adipogen.com/ag-cn2-0023/wortmannin.html ). Antifungal. Phytotoxin. Shows necrotic activity on plants....
Reference: AG-CN2-0127
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Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor [1, 2]. Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) inhibitor [3-7]. Specific M phase inhibitor [4].
Reference: AG-CN2-0128
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Cyclic peptide antibiotic Antibacterial.
Reference: AG-CN2-0129
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Antibiotic. Antibacterial Antifungal. Inhibits the biosynthesis of cyclic peptide quormones in Gram-positive bacteria. Lead compound for antipathogenic drugs that target the quorum-sensing-mediated virulence...
Reference: AG-CN2-0130
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Antibiotic [1]. Antiprotozoal [1]. Antifungal [2]. Anticancer [3-7]. ATP synthesis inhibitior [3, 4]. Haemolytic agent [5]. Antioomycete [8]. Spermidine-induced autoactivation inhibitor [9]. Plasma hyaluronan-binding...
Reference: AG-CN2-0131
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Specific anti-mycobacterial. Inhibits growth of Mycobacteria smegmatis but also Mycobacteria tuberculosis. M. smegmatis is used as a model for mycobacterial species. It is useful for the research analysis of other...
Reference: AG-CN2-0132
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Antibiotic [1]. Pollen growth and development inhibitor [2-4].
Reference: AG-CN2-0133
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Antibiotic [2,3] Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu) [4-7]. Type 3 secretion system (T3SS) inhibitor [8]. Growth promotor in poultry [1].
Reference: AG-CN2-0134
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Antimicrobial [1,2]. Phytotoxic [3]. Specific acetylcholinesterase (AChE) inhibitor [4].
Reference: AG-CN2-0135
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Free radical scavenger and antioxidant [1]. Potential compound to neutralize radioactive and toxic wastes and "heal" soils. Chelates and binds scores of minerals into a bioavailable form used by cells [1]. Shown to...
Reference: AG-CN2-0136
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Antimicrobial [1]. Phytotoxic [1,2].
Reference: AG-CN2-0137
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Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor [1]. HIV-1 integrase inhibitor [2].
Reference: AG-CN2-0138
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Mycotoxin. Antibacterial agent. ADP transport inhibitor. NADH dehydrogenase (NADH-Coenzyme Q oxidoreductase; Complex I) inhibitor. Inhibits mitochondrial respiration and oxidative phosphorylation (OXPHOS). Human CCR5...
Reference: AG-CN2-0139
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Plasminogen activator inhibitor (PAI-1) [1]. Glucose uptake stimulator [2].
Reference: AG-CN2-0140
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Antiprotozoal (Leishmania) [1]. Antifungal [2].
Reference: AG-CN2-0141
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Antibiotic [1]. TNF-alpha-induced NF-kappaB activation inhibitor [1]. Antiangiogenic [1]. Apoptosis inducer [2-4]. Anticancer compound. Selective cytotoxic against several cancer cell lines [2-4]. Tyrosinase inhibitor...
Reference: AG-CN2-0142
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Tremorgenic mycotoxin [1, 2]. Potent and specific, irreversible acetylcholinesterase (AChE) inhibitor [3-7].
Reference: AG-CN2-0143
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Antibiotic [7]. Antifungal penicillide [8]. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor [2]. Strong pp60c-Src inhibitor [3]. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor...
Reference: AG-CN2-0144
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Mycotoxin [1, 5, 7, 8]. Protein farnesyltransferase (PFTase) inhibitor [1-3]. Anti-cancer compound [1-3]. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells [4, 6].
Reference: AG-CN2-0145
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Antibiotic [1]. Anthelmintic agent [1]. Paralytic against Bombyx mori [2, 3].
Reference: AG-CN2-0146
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Antibiotic [1]. Lariat peptide antiviral [1]. Anti-HIV and anti-HSV (Herpes simplex virus) agent [4-6]. Fsr quorum sensing inhibitor [7-9]. Calmodulin-activated myosin light chain kinase (MLCK) inhibitor [2, 3].
Reference: AG-CN2-0147
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Antibiotic [1]. Antiprotozoal [1]. Antifungal and phytotoxic compound [1, 6]. Anti-inflammatory [7]. TGF-beta signaling inhibitor [8] Anticancer compound [2, 9]. Inhibits expression of inducible nitric oxide synthase...
Reference: AG-CN2-0148
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Antibiotic [1, 2]. Antimalaria agent [2].
Reference: AG-CN2-0149
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Antibiotic [1]. Antifungal and antibacterial compound [1, 2, 6]. Specific mitochondrial complex II (succinate ubiquinone oxidoreductase; succinate dehydrogenase) inhibitor [3, 5]. Herbicidal activity [4]. Anthelmintic...
Reference: AG-CN2-0150
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Antibiotic [1, 6]. Anti-mycobacterial [7]. Siderophore (iron (Fe) chelating compound) [5, 8]. Inducer of morphological changes in insect cells [3]. Antioxidant [4]. Anticancer compound [2, 8].
Reference: AG-CN2-0152
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Antibiotic [1, 2]. Cell-cell adhesion inhibitor [1, 2]. Antimetastatic compound [1, 2, 5]. Antifungal [3]. Antimicrobial [4].
Reference: AG-CN2-0154
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Antimitotic. Cell cycle inhibitor at the G2/M phase [3, 4]. Antiproliferative [3]. Weak CNS stimulant with weak inhibitory activity on blood platelet aggregation [1, 2]. Mycotoxin [1].
Reference: AG-CN2-0155
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Antibiotic. Mycotoxin. Very weak cytotoxic activity. Antifungal. Inhibits cell wall biosynthesis. Nerve growth factor (NGF) potentiator.
Reference: AG-CN2-0156
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Antioxidant. Radical scavenging activity towards DPPH and superoxide [3]. Shows a suppressive effect on the expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs)...
Reference: AG-CN2-0157
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Antibiotic [1, 3, 4]. Anti-viral compound [1]. Antifungal (weak) [2]. Anti-protozoal (Trypanosoma, Trichomonas) [2, 5].
Reference: AG-CN2-0158
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Antibiotic [1-3]. Antimycoplasma [1, 3, 4]. Antifungal compound [1, 3]. Anti-malarial agent [5]. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6]. Potential anticancer compound. Inducer...
Reference: AG-CN2-0159
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Antibiotic [1-3]. Active against Gram-positive bacteria [1, 2]. Active against Spodoptera eridania [1, 2].
Reference: AG-CN2-0160
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Antibiotic [1]. Stereoisomer of chrodrimanin B, which is an insecticidal compound [2].
Reference: AG-CN2-0161
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Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not...
Reference: AG-CN2-0162
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Antibiotic [1]. Inducer of morphological deformation of the conidia of Pyricularia oryzae [1].
Reference: AG-CN2-0163
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Derivative of aszonalenin, a substance P inhibitor.
Reference: AG-CN2-0164
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Antibiotic [1-3]. Acetylcholinesterase (AChE) inhibitor [3]. Anti-inflammatory compound [1, 4]. Tumor necrosis factor (TNF) inhibitor [1, 4].
Reference: AG-CN2-0165
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Antibiotic [1, 2, 6]. Antifungal [6]. Nematicidal [4]. Phytotoxic [3]. TGF-beta signaling inhibitor [9] Anticancer compound [5, 6, 8, 10]. Strong activator of the heat shock response [8]. Inhibitor of the appressorium...
Reference: AG-CN2-0166
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Boron-containing macrolide antibiotic [1]. Antibacterial [1]. Antiprotozoal (Plasmodium, Babesia) [2]. Anti-HIV compound [3,6]. Ca2+ homeostasis modulator [4]. Potentiator of bleomycin-induced anti-tumor activity [5]....
Reference: AG-CN2-0167
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Tremorgenic [1]. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels [2]. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)) [3]....
Reference: AG-CN2-0168
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Cytotoxic. Melanogenesis inhibitor without cytotoxicity.
Reference: AG-CN2-0169
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Peptide antibiotic. Antibcaterial [1]. Plant growth stimulator [2]. Induces root curvature and malformation in plants [3]. Mycotoxin [4]. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of...
Reference: AG-CN2-0170
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Weak blood platelet aggregation inhibitor compared to Herquline B.
Reference: AG-CN2-0171
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Anticancer compound. Cytotoxic against human breast cancer cells. Induces autophagic cell death in MCF-7 cells. Moderate radical scavenger. Weak acetylcholinesterase (AChE) inhibitor. Shows moderate trypanocidal...
Reference: AG-CN2-0172
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Mycotoxin. Tetracycline antibiotic. Potent antibacterial agent with activity against several strains of Staphylococcus aureus, including Methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA)....
Reference: AG-CN2-0173
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Selective apoptosis inducer in ras-dependent cells. Autophagy (Akt-dependent), apoptosis and necroptosis inducer in renal cancer cell lines. Induces death of ras-mutated pancreatic tumor (Panc-1) cells in vitro and in...
Reference: AG-CN2-0174
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Potent anticancer agent. Inhibits cell growth, proliferation and survival of human tumor cells lines in vivo and in vitro. Exhibits strong cytotoxicity against a panel of human solid tumor cell lines, disrupting the...
Reference: AG-CN2-0175
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Anthraquinone antibiotic. Red antibacterial agent against Gram positive bacteria. Anticancer agent. Inhibits cell proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. Also shown...
Reference: AG-CN2-0176
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Mycotoxin. Implicated in human and animal toxicosis. Potent cytotoxic and antiproliferative agent against cancer cell lines. Potent antimalarial agent. Antifungal, antibiotic, phototoxic and cytostatic agent....
Reference: AG-CN2-0300
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Tetracyclic class II lantibiotic. Structurally related to mersacidine. Antibiotic. Antibacterial against Gram-positive bacteria and Gram-negative microorganisms. Specifically inhibits peptidoglycan synthesis in the...
Reference: AG-CN2-0302
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Broad spectrum antifungal agent compared to sordarin. Shows growth inhibitory activity against pathogenic fungal strains such as Candida albicans, C. glabrata and Cryptococcus neoformans. Inhibits the protein...
Reference: AG-CN2-0303
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Thiopeptide antibiotic. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens, including methicillin-resistant strains of Staphylococcus aureus and...
Reference: AG-CN2-0304
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Thiopeptide antibiotic. Congener of GE2270A (AG-CN2-0303 https://adipogen.com/ag-cn2-0303-ge2270a.html ). Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic...
Reference: AG-CN2-0305
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Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase (RNAP). Inhibits Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) RNAPs with IC50 ~20nM, whereas it is...
Reference: AG-CN2-0306
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Tetrapeptide antibiotic. Potent and selective inhibitor of bacterial protein synthesis. Translational inhibitor specific for the initiation phase. Binds to the 30S ribosomal subunit and specifically inhibits P-site...
Reference: AG-CN2-0307
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Antibacterial class I lantibiotic. Mixture of two similarly active and structurally related polypeptides (A1, 2246Da and A2, 2230Da) of 24 amino acids linked by 5 intramolecular thioether bridges. Inhibits cell wall...
Reference: AG-CN2-0308
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Antibacterial class I lantibiotic. Brominated variant of NAI-107 (AG-CN2-0307 https://adipogen.com/ag-cn2-0307-nai-107-microbisporicin.html ). Inhibits cell wall synthesis and consequently bacterial growth by forming...
Reference: AG-CN2-0309
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Labionin-containing class III lanthipeptide. Antinociceptive agent. Effective in animal models of nociceptic and inflammatory pain. Does not act through opioid, cannabinoid or descending adrenergic mechanisms. Most...
Reference: AG-CN2-0310
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Actagardin-related class II lantibiotic. Antibacterial with improved activity than actagardine against Staphylococcus spp. and Streptococcus spp. Shows significant activity against Gram-positive anaerobic bacteria,...
Reference: AG-CN2-0311
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Antibacterial class I lantibiotic. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis....
Reference: AG-CN2-0312
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Antibacterial class I lantibiotic. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis....
Reference: AG-CN2-0314
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Cinnamoyl aminoglycoside antibiotic. Protein synthesis inhibitor in vitro. Selective inhibitor of bacterial translation elongation, through binding to the 50S subunit. Inhibits EF-G-dependent mRNA translocation but...
Reference: AG-CN2-0315
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Potent antibacterial agent. Shows MIC values lower than 0.015µg/ml against Gram-positive pathogens, including some antibiotic-resistant strains and selected Gram-negative bacteria.
Reference: AG-CN2-0316
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Peptidyl nucleoside antibiotic. Selective nucleoside-analog inhibitor of bacterial RNA polymerase (RNAP). Inhibits RNAP through a distinctive binding site on RNAP (the NTP addition site) and mechanism (competition...
Reference: AG-CN2-0317
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Rubromycin antibiotic. Antibacterial, antifungal and anti-protozoal agent. Active against Gram-positive bacteria, Gram-negative bacteria and fungi. Telomerase inhibitor (IC50=3µM). Protein synthesis inhibitor. Binds...
Reference: AG-CN2-0318
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Glycolipodepsipeptide antibiotic. Complex of structurally related molecules A1, A2 and A3, with ramoplanin A2 as the primary component. Antibacterial and antiviral agent with activity against aerobic and anaerobic...
Reference: AG-CN2-0320
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Ansamycin antibiotic. Hydrazone of 3-formylrifamycin SV. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).
Reference: AG-CN2-0321
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Ansamycin antibiotic. Intermediate of rifampicin. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and...
Reference: AG-CN2-0322
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Ansamycin antibiotic. Hydrazone of 3-formylrifamycin SV. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP).

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