Vasoactive Eicosanoid HPLC Mixture Reference: 10003-1 This mixture contains the characteristic metabolites of both PGI2 and TXA2. Contents: Thromboxane B2, 11-dehydro Thromboxane B2, 6-keto Prostaglandin F1α, 2,3-dinor-6-keto Prostaglandin F1α (100 µg each), and 12(S)-HHTrE (5 µg).
Ikarugamycin Reference: 15386-2,5 A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in macrophages; inhibits clathrin-coated pit-mediated endocytosis
EZ Cap™ Cas9 mRNA (5-moUTP) Reference: R1015-.1 Used with guideRNA for site-specific DNA cleavage in genome editing.
p-Cymene Reference: 23159-100 A monoterpene with diverse biological activities; inhibits the growth of S. typhimurium, E. coli, L. monocytogenes, S. epidermidis, and S. aureus (MICs = 0.266-0.608% v/v); decreases the invasive activity of HT-1080 human fibrosarcoma cells in vitro by 87% at 600 µM; in mouse hippocampus, reduces lipid peroxidation and nitrite content by 65.5 and 71.2%, respectively, and increases SOD and catalase activities by 22.7 and 119.3%, respectively, compared to vehicle control animals, at 50 mg/kg
4-oxo-2-Nonenal-d3 Reference: 10004174-1 4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.
Cercosporamide Reference: 15500-2,5 A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells